A
Alfredo A. Sadun
Researcher at University of California, Los Angeles
Publications - 471
Citations - 17682
Alfredo A. Sadun is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Optic nerve & Optic neuropathy. The author has an hindex of 65, co-authored 455 publications receiving 15510 citations. Previous affiliations of Alfredo A. Sadun include Boston Medical Center & St. Marianna University School of Medicine.
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Journal ArticleDOI
Mitochondrial dysfunction as a cause of optic neuropathies
TL;DR: The recent identification of mutations in the nuclear gene OPA1 as the causative factor in dominant optic atrophy (DOA) brought the unexpected finding that this gene encodes for a mitochondrial protein, suggesting that DOA and LHON may be linked by similar pathogenesis.
Journal ArticleDOI
Optic-Nerve Degeneration in Alzheimer's Disease
TL;DR: The changes observed in the patients with Alzheimer's disease were clearly distinguishable from the findings in 10 age-matched controls and represent a sensory-system degeneration that occurs in Alzheimer’s disease.
Journal ArticleDOI
Optic Nerve Decompression Surgery for Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) Is Not Effective and May Be Harmful
Frank Ischemic,Frank J. Hooper,David Kaufman,Nancy J. Newman,P. David Wilson,Z. Suzanne Zam,John S. Kennerdell,Anna Tyutyunikov,Russell Edwards,Todd Goodglick,Deborah Lang,Kimberly Peele,Sophia M. Chung,Diana Mekelburg,John B. Holds,John B. Selhorst,Mark Malton,Sonia Armstrong,Yvonne Mccracken,Eugene Benjamin,Carol Dellinger,Traci Hunter Medlin,Barbara Kinsler,Mike Mcowen,Donna Russell,Timothy Saunders,Gregory S. Kosmorsky,Tina Kiss,Cate Reinhard,Laura Venne,Janet Edgerton,Tami Fecko,Susannah Hanson,Brian Kraus,Deborah Ross,Nancy Tomsak,Pamela Vargo,Rufus Willis,Steven E. Feldon,Kerry Zimmerman,Kristin E. Anderson,Richard Cortez,Karen Deblanc,Judy Hulse,Ronald B. Morales,Tracy Nichols,Lillian Reyes,Nadine Rodarte Ochoa,Daniel Romo,Alfredo A. Sadun,Mary Steber,Frances Walonker,Donna Loupe,Diana Coffman,Harvey Cole,Ted H. Wojno,Barry Skarf,Colleen Wojtala,Mark Croswell,Wendy Gilroy,Christian Mageli,Dena McDonald,George Ponka,Rosa A. Tang,Melissa Hamlin,Jewel Curtis,Jay Forman,Kenneth Hyde,Kirk Mack,Portia Tello,Anthony C. Arnold,Berniee Cibener,Melody Acero,Bobbi Ballenberg,Anne Bolton,Robert J. Goldberg,Lynn K. Gordon,Michael A. Heneghan,Howard R. Krauss,Jackie Sanguinei,Robert Stalling,Jenja Yadegaran,Wayne T. Cornblath,Barbara Michael,Donna Campbell,Cheryl Caudill,Christine Nelson,Jonathan D. Trobe,Lenworth N. Johnson,Gaye Baker,Coy Cobb,Philip Custer,Sharon Turner,Roy D. Wilson,Brian R. Younge,Jacqueline A. Leavitt,Rebecca Nielsen,Jody Allen,Barbara Eickhoff,James A. Garrity,Jacqueline Ladsten,Kathleen Lebarron,Thomas P. Link,Jay A. Rostvold,Karen Weber,Warren L. Felton,Tracy Boney,Danielle Gabriel,Daniel David,Lahn Fendelander,Daniel Geller,Timothy R. Jordan,Christian Kim,Craig Munger,Anne Romandy,George Sanborn,Bradley Schwartz,Carl Sheusi,Constance Smith,Kathy Talley,Sandya Thimmappa,Eric R. Eggenberger,Suzanne Bickert,Robert Granadier,Sandra Holliday,Thomas J. Moore,Jaya Varadarajan,Deborah I. Friedman,Patricia Jones,Haris Amin,Thomas A. Bersani,Cynthia Briglin,James Fooks,Michael Graham,Milton James,Gary Michalec,Hoang Nguyen,Jonathan C. Horton,Maeve Chang,Lou Anne Aber,Erik Lindstrom,Stuart R. Seiff,John Guy,Amye Francis,Latif Hamed,Alan Lessner,Donna Mcdavid,Diana Shamis,James S. Goodwin,Martin E. Lindeman,Allen M. Putterman,Phyllis Bobak,Robert Baker,Judy Beck,David L. Cowen,Avrom Epstein,M.B. Hanson,Toni Scoggins,Ann M. Rodavitch,Brenda Gore,Andrea Blake,Michele Heroux,Rani Kalsi,Charlene Krauch,Mary Ann Millar,Mitchell Wolin,Rita Jean Brady,Regina Hansen,Michael Briggs,Karkarla V. Chalam,Barbara Danner,Beverly Simons,Anne Stewart,Kathleen B. Digre,Lizbeth Malmquist Webb,Terrell Blackburn,Susan Baggaley,Richard C. E. Anderson,Charles Juarez,Bonnie Kaye,Paul D. Langer,Aditya Mishra,Paula Morris,Sandra Osborn,Bhupendra C. Patel,Tessie Priskos,Sandra Staker,Judith E. A. Warner,Christine Evans,Allison Aylor,Carolyn Childress,Helen Dickerson,Jane Fleming,Nomine Harris,L. Sharon Hoyle,Ellen Murphy,James Scott,Karen Summerville,Mariann Terrell,Lillian Tyler,John V. Linberg,Lenore Breen,Michelle Michael,Charlene Campbell,Brian Ellis,Nancy Groves,Robert Hobson,Gordon Mcgregor,Laura Shepherd,Edward S. Cohn,Patricia Manatrey,Sara Casey,John W. Johnson,Coletti Kronner,Virginia Regan,Patricia Streasick,Shalom E. Kelman,Michael J. Elman,Aim M. Rodavitch,Roberta W. Scherer,Barbara Crawley,Cheryl Hiner,Lucy Howard,Patricia Langenberg,Olga Lurye,Sara Riedel,Michelle Sotos,Laureen Spioch,Joann Starr,Judy Urban,Mark Waring,Donald Everett,Kay Dickersin,Robert McCarter,Stuart R. Seiff +234 more
TL;DR: Results from the Ischemic Optic Neuropathy Decompression Trial indicate that optic nerve decompression surgery for NAION is not effective, may be harmful, and should be abandoned.
Journal ArticleDOI
Treatment of unresectable meningiomas with the antiprogesterone agent mifepristone.
Steven M. Grunberg,Martin H. Weiss,Irving M. Spitz,Jamshid Ahmadi,Alfredo A. Sadun,Christy A. Russell,Lois Lucci,Lani L. Stevenson +7 more
TL;DR: Long-term therapy with mifepristone is a new therapeutic option that may have efficacy in cases of unresectable benign meningioma and has shown signs of objective response and subjective improvement in five patients.
Journal ArticleDOI
Clinical Expression of Leber Hereditary Optic Neuropathy Is Affected by the Mitochondrial DNA–Haplogroup Background
Gavin Hudson,Valerio Carelli,Valerio Carelli,Liesbeth Spruijt,Mike Gerards,Catherine Mowbray,Alessandro Achilli,Angela Pyle,Joanna L. Elson,Neil Howell,Chiara La Morgia,Maria Lucia Valentino,Kirsi Huoponen,Marja-Liisa Savontaus,Eeva Nikoskelainen,Alfredo A. Sadun,Solange Rios Salomão,Rubens Belfort,Philip G. Griffiths,Patrick Yu Wai Man,René de Coo,Rita Horvath,Massimo Zeviani,Hubert J T Smeets,Antonio Torroni,Patrick F. Chinnery +25 more
TL;DR: It is shown that the risk of visual failure is greater when the 11778G-->A or 14484T-->C mutations are present in specific subgroups of haplogroup J and when the 3460G -->A mutation is present in haplogroups K and K, and significantly less when 11778g-->A occurs in haplogiroup H.