P
Piero Barboni
Researcher at Vita-Salute San Raffaele University
Publications - 196
Citations - 9477
Piero Barboni is an academic researcher from Vita-Salute San Raffaele University. The author has contributed to research in topics: Leber's hereditary optic neuropathy & Optic neuropathy. The author has an hindex of 51, co-authored 178 publications receiving 8030 citations. Previous affiliations of Piero Barboni include Sapienza University of Rome & University of California, Berkeley.
Papers
More filters
Journal Article
Haplotype and phylogenetic analyses suggest that one European-specific mtDNA background plays a role in the expression of Leber hereditary optic neuropathy by increasing the penetrance of the primary mutations 11778 and 14484
Antonio Torroni,M. Petrozzi,Leila D'Urbano,Daniele Sellitto,Massimo Zeviani,Franco Carrara,Claudia Carducci,Vincenzo Leuzzi,Valerio Carelli,Piero Barboni,A. De Negri,Rosaria Scozzari +11 more
TL;DR: This analysis shows that the putative secondary/intermediate LHON mutations 4216, 4917, 13708, 15257, and 15812 are ancient polymorphisms, are associated in specific combinations, and define two common Caucasoid-specific haplotypes (haplogroups J and T).
Journal ArticleDOI
Melanopsin retinal ganglion cell loss in Alzheimer disease
Chiara La Morgia,Fred N. Ross-Cisneros,Yosef Koronyo,Jens Hannibal,Roberto Gallassi,Gaetano Cantalupo,Luisa Sambati,Billy X. Pan,Kevin R. Tozer,Piero Barboni,Federica Provini,Pietro Avanzini,Michele Carbonelli,Annalisa Pelosi,Helena C. Chui,Rocco Liguori,Agostino Baruzzi,Maya Koronyo-Hamaoui,Alfredo A. Sadun,Valerio Carelli +19 more
TL;DR: This work investigated mRGCs in AD, hypothesizing that they contribute to circadian dysfunction, and confirmed their role in photoreceptors driving circadian photoentraining.
Journal ArticleDOI
Efficient mitochondrial biogenesis drives incomplete penetrance in Leber's hereditary optic neuropathy.
Carla Giordano,Luisa Iommarini,Luca Giordano,Alessandra Maresca,Annalinda Pisano,Maria Lucia Valentino,Leonardo Caporali,Rocco Liguori,Stefania Deceglie,Marina Roberti,Francesca Fanelli,Flavio Fracasso,Fred N. Ross-Cisneros,Pio D'Adamo,Gavin Hudson,Angela Pyle,Patrick Yu-Wai-Man,Patrick F. Chinnery,Massimo Zeviani,Solange Rios Salomão,Adriana Berezovsky,Rubens Belfort,Dora Fix Ventura,Milton Rocha Moraes,Milton Moraes Filho,Piero Barboni,Federico Sadun,Annamaria De Negri,Alfredo A. Sadun,Andrea Tancredi,Massimiliano Mancini,Giulia d'Amati,Paola Loguercio Polosa,Palmiro Cantatore,Valerio Carelli +34 more
TL;DR: Giordano et al. show that mitochondrial DNA content and mitochondrial mass are both increased in tissues and cells from unaffected mutation carriers relative to affected relatives and control individuals, suggesting upregulation of mitochondrial biogenesis may represent a therapeutic target.
Journal ArticleDOI
Retinal nerve fiber layer evaluation by optical coherence tomography in Leber's hereditary optic neuropathy.
Piero Barboni,Giacomo Savini,Maria Lucia Valentino,Pasquale Montagna,Pietro Cortelli,Anna Maria De Negri,Federico Sadun,Stefania Bianchi,Lora Longanesi,Maurizio Zanini,Antonello de Vivo,Valerio Carelli +11 more
TL;DR: On the basis of OCT data, the RNFL is thickened in E-LHON and severely thinned in A- lHON; the temporal fibers are the first and most severely affected; the nasal fibers seem to be partially spared in the late stage of the disease.
Journal ArticleDOI
Correlation between retinal nerve fibre layer thickness and optic nerve head size: an optical coherence tomography study
Giacomo Savini,Maurizio Zanini,Valerio Carelli,Alfredo A. Sadun,Fred N. Ross-Cisneros,Piero Barboni +5 more
TL;DR: RNFL thickness measurements obtained by Stratus OCT increased significantly with an increase in optic disc size, and it is not clear if eyes with large ONHs show a thicker RNFL as a result of an increased amount of nerve fibres or to the shorter distance between the circular scan and the optic disc edge.