D
Doris F. Cully
Researcher at Merck & Co.
Publications - 53
Citations - 6536
Doris F. Cully is an academic researcher from Merck & Co.. The author has contributed to research in topics: Chloride channel & Avermectin. The author has an hindex of 25, co-authored 53 publications receiving 6214 citations. Previous affiliations of Doris F. Cully include Merial & Netherlands Cancer Institute.
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Journal ArticleDOI
A Receptor in Pituitary and Hypothalamus That Functions in Growth Hormone Release
Andrew D. Howard,Scott D. Feighner,Doris F. Cully,Joseph P. Arena,Paul A. Liberator,Charles Rosenblum,Michel J. Hamelin,Donna L. Hreniuk,Oksana C. Palyha,Jennifer W. Anderson,Philip S. Paress,Carmen Diaz,Michael Chou,Ken K. Liu,Karen K. McKee,Sheng-Shung Pong,Lee-Yuh Chaung,Alex Elbrecht,Mike Dashkevicz,Robert P. Heavens,Michael Rigby,Dalip J. S. Sirinathsinghji,Dennis C. Dean,David G. Melillo,Arthur A. Patchett,Ravi P. Nargund,Patrick R. Griffin,Julie A. DeMartino,Sunil Gupta,James M. Schaeffer,Roy G. Smith,Lex H.T. Van der Ploeg +31 more
TL;DR: A heterotrimeric GTP-binding protein (G protein)-coupled receptor (GPC-R) of the pituitary and arcuate ventro-medial and infundibular hypothalamus of swine and humans was cloned and was shown to be the target of the GHSs.
Journal ArticleDOI
Platensimycin is a selective FabF inhibitor with potent antibiotic properties
Jun Wang,Stephen M. Soisson,Katherine Young,Wesley L. Shoop,Wesley L. Shoop,Srinivas Kodali,Andrew Galgoci,Ronald E. Painter,Gopalakrishnan Parthasarathy,Yui S. Tang,Richard D. Cummings,Sookhee Ha,Karen Dorso,Mary Motyl,Hiranthi Jayasuriya,John G. Ondeyka,Kithsiri Herath,Chaowei Zhang,Lorraine D. Hernandez,John J. Allocco,Angela Basilio,José R. Tormo,Olga Genilloud,Francisca Vicente,Fernando Pelaez,Lawrence F. Colwell,Sang Ho Lee,B.F. Michael,Thomas J. Felcetto,Charles Gill,Lynn L. Silver,Lynn L. Silver,Jeffery D. Hermes,Ken Bartizal,John F. Barrett,Dennis M. Schmatz,Joseph W. Becker,Doris F. Cully,Sheo B. Singh +38 more
TL;DR: Platensimycin demonstrates strong, broad-spectrum Gram-positive antibacterial activity by selectively inhibiting cellular lipid biosynthesis through the selective targeting of β-ketoacyl-(acyl-carrier-protein (ACP) in the synthetic pathway of fatty acids.
Journal ArticleDOI
Cloning of an avermectin-sensitive glutamate-gated chloride channel from Caenorhabditis elegans
Doris F. Cully,Demetrios K. Vassilatis,Ken K. Liu,Philip S. Paress,Lex H.T. Van der Ploeg,James M. Schaeffer,Joseph P. Arena +6 more
TL;DR: The electrophysiological and structural properties of these proteins indicate that they are new members of the ligand-gated ion channel superfamily.
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Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties.
Jun Wang,Srinivas Kodali,Sang Ho Lee,Andrew Galgoci,Ronald E. Painter,Karen Dorso,Fred Racine,Mary Motyl,Lorraine D. Hernandez,Elizabeth Tinney,Steven L. Colletti,Kithsiri Herath,Richard D. Cummings,Oscar Salazar,Ignacio González,Angela Basilio,Francisca Vicente,Olga Genilloud,Fernando Pelaez,Hiranthi Jayasuriya,Katherine Young,Doris F. Cully,Sheo B. Singh +22 more
TL;DR: Platencin shows potent in vivo efficacy without any observed toxicity, emphasizing the fact that more antibiotics with novel structures and new modes of action can be discovered by using this antisense differential sensitivity whole-cell screening paradigm.
Journal ArticleDOI
Identification of a Drosophila melanogaster Glutamate-gated Chloride Channel Sensitive to the Antiparasitic Agent Avermectin
TL;DR: The pharmacological data support the hypothesis that the DrosGluCl-α channel represents the arthropod H-receptor and an important target for the avermectin class of insecticides.