K
Karen Dorso
Researcher at Merck & Co.
Publications - 27
Citations - 2169
Karen Dorso is an academic researcher from Merck & Co.. The author has contributed to research in topics: Antibacterial agent & Platensimycin. The author has an hindex of 20, co-authored 27 publications receiving 2022 citations.
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Journal ArticleDOI
Platensimycin is a selective FabF inhibitor with potent antibiotic properties
Jun Wang,Stephen M. Soisson,Katherine Young,Wesley L. Shoop,Wesley L. Shoop,Srinivas Kodali,Andrew Galgoci,Ronald E. Painter,Gopalakrishnan Parthasarathy,Yui S. Tang,Richard D. Cummings,Sookhee Ha,Karen Dorso,Mary Motyl,Hiranthi Jayasuriya,John G. Ondeyka,Kithsiri Herath,Chaowei Zhang,Lorraine D. Hernandez,John J. Allocco,Angela Basilio,José R. Tormo,Olga Genilloud,Francisca Vicente,Fernando Pelaez,Lawrence F. Colwell,Sang Ho Lee,B.F. Michael,Thomas J. Felcetto,Charles Gill,Lynn L. Silver,Lynn L. Silver,Jeffery D. Hermes,Ken Bartizal,John F. Barrett,Dennis M. Schmatz,Joseph W. Becker,Doris F. Cully,Sheo B. Singh +38 more
TL;DR: Platensimycin demonstrates strong, broad-spectrum Gram-positive antibacterial activity by selectively inhibiting cellular lipid biosynthesis through the selective targeting of β-ketoacyl-(acyl-carrier-protein (ACP) in the synthetic pathway of fatty acids.
Journal ArticleDOI
Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties.
Jun Wang,Srinivas Kodali,Sang Ho Lee,Andrew Galgoci,Ronald E. Painter,Karen Dorso,Fred Racine,Mary Motyl,Lorraine D. Hernandez,Elizabeth Tinney,Steven L. Colletti,Kithsiri Herath,Richard D. Cummings,Oscar Salazar,Ignacio González,Angela Basilio,Francisca Vicente,Olga Genilloud,Fernando Pelaez,Hiranthi Jayasuriya,Katherine Young,Doris F. Cully,Sheo B. Singh +22 more
TL;DR: Platencin shows potent in vivo efficacy without any observed toxicity, emphasizing the fact that more antibiotics with novel structures and new modes of action can be discovered by using this antisense differential sensitivity whole-cell screening paradigm.
Journal ArticleDOI
Discovery of a Small Molecule That Inhibits Cell Division by Blocking FtsZ, a Novel Therapeutic Target of Antibiotics *
Jun Wang,Andrew Galgoci,Srinivas Kodali,Kithsiri Herath,Hiranthi Jayasuriya,Karen Dorso,Francisca Vicente,Antonio Gonzalez,Doris F. Cully,David Bramhill,Sheo B. Singh +10 more
TL;DR: Viriditoxin exhibited broad-spectrum antibacterial activity against clinically relevant Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococci, without affecting the viability of eukaryotic cells.
Journal ArticleDOI
Discovery of Kibdelomycin, A Potent New Class of Bacterial Type II Topoisomerase Inhibitor by Chemical-Genetic Profiling in Staphylococcus aureus
John W. Phillips,Michael A. Goetz,Scott K. Smith,Deborah L. Zink,Jon D. Polishook,Russell Onishi,Scott P. Salowe,Judyann Wiltsie,John J. Allocco,Janet M. Sigmund,Karen Dorso,Suzy Lee,Stephen Skwish,Mercedes de la Cruz,Jesús Martín,Francisca Vicente,Olga Genilloud,Jun Lu,Ronald E. Painter,Katherine Young,Karen M. Overbye,Robert G. K. Donald,Sheo B. Singh +22 more
TL;DR: Kibdelomycin is the first truly novel bacterial type II topoisomerase inhibitor with potent antibacterial activity discovered from natural product sources in more than six decades.
Journal ArticleDOI
Chemical Genetic Identification of Peptidoglycan Inhibitors Potentiating Carbapenem Activity against Methicillin-Resistant Staphylococcus aureus
Joann Huber,Robert G. K. Donald,Sang Ho Lee,Lisa Wang Jarantow,Michael J. Salvatore,Xin Meng,Ronald E. Painter,Russell Onishi,James L. Occi,Karen Dorso,Katherine Young,Young Whan Park,Stephen Skwish,Michael J. Szymonifka,Tim S. Waddell,Lynn Miesel,John W. Phillips,Terry Roemer +17 more
TL;DR: These results suggest that SAV1754 inhibitors might possess therapeutic potential alone, or in combination with beta-lactams to restore MRSA efficacy, and speculate it performs an analogous function in S. aureus.