F
Frederic Picard
Researcher at Massachusetts Institute of Technology
Publications - 6
Citations - 3458
Frederic Picard is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Adipogenesis & Adipose tissue. The author has an hindex of 6, co-authored 6 publications receiving 3305 citations.
Papers
More filters
Journal ArticleDOI
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma.
Frederic Picard,Martin Kurtev,Namjin Chung,Acharawan Topark-Ngarm,Thanaset Senawong,Rita Machado de Oliveira,Rita Machado de Oliveira,Mark Leid,Michael W. McBurney,Leonard Guarente +9 more
TL;DR: It is shown that the mammalian SIR2 orthologue, Sirt1 (sirtuin 1), activates a critical component of calorie restriction in mammals; that is, fat mobilization in white adipocytes.
Journal ArticleDOI
Calorie Restriction— the SIR2 Connection
Leonard Guarente,Frederic Picard +1 more
TL;DR: It is proposed that Sirt1 regulates calorie restriction by sensing low calories and triggering physiological changes linked to health and longevity.
Journal ArticleDOI
Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells.
Laura Bordone,Maria Carla Motta,Frederic Picard,Ashley Robinson,Ulupi S. Jhala,Javier Apfeld,Thomas McDonagh,Madeleine E. Lemieux,Michael W. McBurney,Akos Szilvasi,Erin J. Easlon,Su Ju Lin,Leonard Guarente +12 more
TL;DR: It is shown that Sirt1 positively regulates insulin secretion in pancreatic β cells, and regulates UCP2 in β cells to affect insulin secretion, which causes the defect in glucose-stimulated insulin secretion.
Journal ArticleDOI
Correction: Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic ß Cells
Laura Bordone,Maria Carla Motta,Frederic Picard,Ashley Robinson,Ulupi S. Jhala,Javier Apfeld,Thomas McDonagh,Madeleine E. Lemieux,Michael W. McBurney,Akos Szilvasi,Erin J. Easlon,Su Ju Lin,Leonard Guarente +12 more
TL;DR: In the first paragraph of the Materials and Methods subsection of the article as discussed by the authors, it was stated that the SiRNA-T1 (5′-GCTGCATCCAAGGGCCATG-3′) should be changed to pSUPERretro SiRNA T1 ( 5′-gatgaagttgacctcctca-3´) instead of pSUPARretro siRNA T 1 (5´-gatgagttccta-3''.
Patent
SIRT1 Modulation of Adipogenesis and Adipose Function
Leonard Guarente,Frederic Picard +1 more
TL;DR: SIRT1 regulates the physiology of cells of the adipocyte lineage and can be used to ameliorate, treat, or prevent diseases and disorders associated with adipose physiology, eg, obesity, an obesity-related disease, or a fat-related metabolic disorder.