Frédéric Torossian

TL;DR: Overall, the first clinically relevant model of NHO is developed and it is demonstrated that a combined insult of neurological injury and soft tissue inflammation drives NHO pathophysiology.

TL;DR: The evidence of HSCs in ectopic bones growing at the expense of soft tissue in spinal cord/brain-injured patients indicates that inflammation and muscle contribute to HSC regulation by the brain-bone-blood triad.

TL;DR: It is shown here that CXCL12 was capable of binding CXCR7 despite its scarce expression at CD34(+) cell surface, and evidence is provided for the involvement of β-arrestins as signaling hubs downstream of both CxCL12 receptors in primary human HSPCs.

TL;DR: This study shows that bone marrow MSCs from primary myelofibrosis patients exhibit unique molecular and functional abnormalities distinct from other myeloproliferative neoplasms and these abnormalities are maintained stably ex vivo in the absence of leukemic cells, suggesting that combined targeting of both the hematopoietic and stromal cell compartments in primaryMyelofIBrosis patients may heighten therapeutic efficacy.

TL;DR: It is demonstrated that SP phenotype acquisition/reactivation by circulating lin− cells is dependent on interactions with MSCs through VLA-4/α4β1-integrin and CD44, which suggests an extrinsic regulation of ATP-binding cassette-transporter activity that could be of importance for a better understanding of adhesion-mediated chemoresistance mechanisms.