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Adrienne Anginot
Researcher at French Institute of Health and Medical Research
Publications - 18
Citations - 660
Adrienne Anginot is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Stromal cell & Mesenchymal stem cell. The author has an hindex of 11, co-authored 13 publications receiving 515 citations. Previous affiliations of Adrienne Anginot include Université Paris-Saclay & University of Paris-Sud.
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Journal ArticleDOI
Neurological heterotopic ossification following spinal cord injury is triggered by macrophage-mediated inflammation in muscle
François Genêt,François Genêt,Irina Kulina,Cedryck Vaquette,Frédéric Torossian,Frédéric Torossian,Susan M. Millard,Allison R. Pettit,Natalie A. Sims,Adrienne Anginot,Adrienne Anginot,Bernadette Guerton,Bernadette Guerton,Ingrid G. Winkler,Valerie Barbier,Jean-Jacques Lataillade,Marie-Caroline Le Bousse-Kerdilès,Marie-Caroline Le Bousse-Kerdilès,Dietmar W. Hutmacher,Jean-Pierre Levesque +19 more
TL;DR: Overall, the first clinically relevant model of NHO is developed and it is demonstrated that a combined insult of neurological injury and soft tissue inflammation drives NHO pathophysiology.
Journal ArticleDOI
RNA viruses promote activation of the NLRP3 inflammasome through cytopathogenic effect-induced potassium efflux
Leandro Silva da Costa,Leandro Silva da Costa,Ahmed Outlioua,Ahmed Outlioua,Ahmed Outlioua,Adrienne Anginot,Adrienne Anginot,Khadija Akarid,Damien Arnoult,Damien Arnoult +9 more
TL;DR: It is reported that the replication of cytopathogenic RNA viruses such as vesicular stomatitis virus or encephalomyocarditis virus induced a lytic cell death leading to potassium efflux, the common trigger of NLRP3 inflammasome activation.
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Osteoclast activity modulates B-cell development in the bone marrow
Anna Mansour,Adrienne Anginot,Stéphane J. C. Mancini,Claudine Schiff,Georges F. Carle,Georges F. Carle,Abdelilah Wakkach,Abdelilah Wakkach,Abdelilah Wakkach,Claudine Blin-Wakkach,Claudine Blin-Wakkach,Claudine Blin-Wakkach +11 more
TL;DR: The data revealed that OCLs modulate B-cell development in the bone marrow by controlling the bone microenvironment and the fate of osteoblasts, and provide novel basis for the regulation of the retention of B cells in their niche by OCL activity.
Journal ArticleDOI
Macrophage-derived oncostatin M contributes to human and mouse neurogenic heterotopic ossifications.
Frédéric Torossian,Bernadette Guerton,Adrienne Anginot,Kylie A. Alexander,Christophe Desterke,Sabrina Soave,Hsu-Wen Tseng,Nassim Arouche,Laetitia Boutin,Irina Kulina,Marjorie Salga,Marjorie Salga,Beulah Jose,Allison R. Pettit,Denis Clay,Nathalie Rochet,Erica Vlachos,Guillaume Genet,Charlotte Debaud,Philippe Denormandie,François Genêt,Natalie A. Sims,Sébastien Banzet,Jean-Pierre Levesque,Jean-Jacques Lataillade,Marie-Caroline Le Bousse-Kerdilès +25 more
TL;DR: The evidence of HSCs in ectopic bones growing at the expense of soft tissue in spinal cord/brain-injured patients indicates that inflammation and muscle contribute to HSC regulation by the brain-bone-blood triad.
Journal ArticleDOI
Brain and bone damage in KARAP/DAP12 loss-of-function mice correlate with alterations in microglia and osteoclast lineages
Serge Nataf,Adrienne Anginot,Carine Vuaillat,Luc Malaval,Nassima Fodil,Emmanuel Chereul,Jean-Baptiste Langlois,Christiane Dumontel,Gaëlle Cavillon,Christian Confavreux,Marlène Mazzorana,Laurence Vico,Marie-Franaçoise Belin,Eric Vivier,Elena Tomasello,Pierre Jurdic +15 more
TL;DR: The results confirm that KARAP/DAP12-mediated signals play an important role in the regulation of both brain and bone homeostasis and raise the intriguing possibility that defective microglial cell differentiation might be responsible for abnormal myelin development.