F
Freya M. Mowat
Researcher at North Carolina State University
Publications - 50
Citations - 1405
Freya M. Mowat is an academic researcher from North Carolina State University. The author has contributed to research in topics: Retina & Retinal. The author has an hindex of 12, co-authored 45 publications receiving 1161 citations. Previous affiliations of Freya M. Mowat include University of Wisconsin-Madison & University College London.
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Journal ArticleDOI
Long-Term Effect of Gene Therapy on Leber’s Congenital Amaurosis
James W B Bainbridge,James W B Bainbridge,Manjit S Mehat,Venki Sundaram,Scott J Robbie,S. E. Barker,Caterina Ripamonti,Anastasios Georgiadis,Anastasios Georgiadis,Freya M. Mowat,Freya M. Mowat,Stuart G Beattie,Peter Gardner,Kecia L. Feathers,Vy Luong,Suzanne Yzer,Kamaljit S. Balaggan,Kamaljit S. Balaggan,Ananth C. Viswanathan,Thomy de Ravel,Ingele Casteels,Graham E. Holder,Nick Tyler,Fred W. Fitzke,Richard G. Weleber,Marko Nardini,Marko Nardini,Anthony T. Moore,Anthony T. Moore,Debra A. Thompson,Simon M. Petersen-Jones,Michel Michaelides,Michel Michaelides,L. Ingeborgh van den Born,Andrew Stockman,Alexander J. Smith,Gary S. Rubin,Robin R. Ali,Robin R. Ali +38 more
TL;DR: In dogs, RPE65 gene therapy with the same vector at lower doses improved vision-guided behavior, but only higher doses resulted in improvements in retinal function that were detectable with the use of ERG, and comparison with the results obtained in the dog model indicates that there is a species difference in the amount of R PE65 required to drive the visual cycle.
Journal Article
Topographical characterization of cone photoreceptors and the area centralis of the canine retina.
Freya M. Mowat,Simon M. Petersen-Jones,Helen Williamson,David L. Williams,Philip J. Luthert,Robin R. Ali,James W B Bainbridge +6 more
TL;DR: The area centralis was identified as the site of maximal density of rod and cone photoreceptor cells, which have a smaller inner segment cross-sectional area in this region, and the distribution of rods and cone subtypes within the canine retina was described and a predictable location was calculated.
Journal ArticleDOI
Tyrosine capsid-mutant AAV vectors for gene delivery to the canine retina from a subretinal or intravitreal approach.
Freya M. Mowat,Kara R. Gornik,Astra Dinculescu,Sanford L. Boye,William W. Hauswirth,Simon M. Petersen-Jones,Joshua T. Bartoe +6 more
TL;DR: Subretinally delivered capsid-mutant AAV8 vectors may increase the efficacy of gene therapy treatment for rapid photoreceptor degenerative diseases and show promise for retinal gene delivery from an intravitreal approach.
Journal ArticleDOI
The tight junction associated signalling proteins ZO-1 and ZONAB regulate retinal pigment epithelium homeostasis in mice.
Anastasios Georgiadis,M. Tschernutter,James W B Bainbridge,Kamaljit S. Balaggan,Freya M. Mowat,Emma L. West,Peter M. G. Munro,Adrian J. Thrasher,Karl Matter,Maria S. Balda,Robin R. Ali,Robin R. Ali +11 more
TL;DR: It is demonstrated that ZO-1 and ZONAB are critical for differentiation and homeostasis of the RPE monolayer and may be involved in RPE disorders such as proliferative vitroretinopathy and atrophic age-related macular degeneration.
Journal ArticleDOI
HIF-1alpha and HIF-2alpha Are Differentially Activated in Distinct Cell Populations in Retinal Ischaemia
Freya M. Mowat,Ulrich F O Luhmann,Alexander J. Smith,Clemens Lange,Yanai Duran,Sarah K. Harten,Deepa Shukla,Patrick H. Maxwell,Robin R. Ali,James W B Bainbridge +9 more
TL;DR: The findings suggest that HIF-2alpha activation plays a key role in regulating the response of Müller glia to hypoxia, consistent with differential roles in retinal ischaemia.