Friedemann Weber

TL;DR: It is shown that influenza A virus infection does not generate dsRNA and that RIG-I is activated by viral genomic single-stranded RNA (ssRNA) bearing 5′-phosphates, and suggested that its ability to sense 5'-phosphorylated RNA evolved in the innate immune system as a means of discriminating between self and nonself.

TL;DR: Investigation of the presence and localization of ds RNA in cells infected with a range of viruses, employing a dsRNA-specific antibody for immunofluorescence analysis revealed that significant amounts ofdsRNA can be detected for viruses with a genome consisting of positive-strand RNA, dsRNAs, or DNA; Surprisingly, however, no DsRNA signals were detected for negative-stranded RNA viruses.

TL;DR: The current view on the balancing act between virus-induced IFN responses and the viral counterplayers is discussed.

TL;DR: It is proposed that the IFIT complex antagonizes viruses by sequestering specific viral nucleic acids through its binding to PPP-RNA.

TL;DR: There is a high proportion of patients with circulating tumor cells under steady-state conditions, and in addition a substantial risk of concomitant tumor cell recruitment upon mobilization of PBPCs, particularly in stage IV breast cancer patients with bone marrow infiltration.