Søren R. Paludan

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: IFI16 (p204) is the first PYHIN protein to their knowledge shown to be involved in IFN-β induction and forms a new family of innate DNA sensors the authors call 'AIM2-like receptors' (ALRs).

TL;DR: Investigation of the presence and localization of ds RNA in cells infected with a range of viruses, employing a dsRNA-specific antibody for immunofluorescence analysis revealed that significant amounts ofdsRNA can be detected for viruses with a genome consisting of positive-strand RNA, dsRNAs, or DNA; Surprisingly, however, no DsRNA signals were detected for negative-stranded RNA viruses.

TL;DR: Progress is described in understanding signaling mechanisms activated by DNA and the relevance of DNA sensing to pathogen responses and autoimmunity and new insights are highlighted into how and why the immune system responds to both pathogen and self DNA.

TL;DR: In this paper, the authors show that several classes of viruses induce expression of IFN-λ1 and -λ2/3 in similar patterns, and they identify type III IFNs as IFN stimulated genes.