T
Tanja I. Näslund
Researcher at Karolinska Institutet
Publications - 17
Citations - 3828
Tanja I. Näslund is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Immune system & Microvesicles. The author has an hindex of 11, co-authored 17 publications receiving 3530 citations. Previous affiliations of Tanja I. Näslund include Karolinska University Hospital.
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Journal ArticleDOI
RIG-I-Mediated Antiviral Responses to Single-Stranded RNA Bearing 5' Phosphates
Andreas Pichlmair,Oliver Schulz,Choon Ping Tan,Tanja I. Näslund,Peter Liljeström,Friedemann Weber,Caetano Reis e Sousa +6 more
TL;DR: It is shown that influenza A virus infection does not generate dsRNA and that RIG-I is activated by viral genomic single-stranded RNA (ssRNA) bearing 5′-phosphates, and suggested that its ability to sense 5'-phosphorylated RNA evolved in the innate immune system as a means of discriminating between self and nonself.
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Toll-like receptor 3 promotes cross-priming to virus-infected cells
Oliver Schulz,Sandra S. Diebold,Margaret Chen,Tanja I. Näslund,Martijn A. Nolte,Lena Alexopoulou,Lena Alexopoulou,Yasu-Taka Azuma,Richard A. Flavell,Peter Liljeström,Caetano Reis e Sousa +10 more
TL;DR: It is shown that murine CD8α+ dendritic cells are activated by double-stranded (ds)RNA present in virally infected cells but absent from uninfected cells, which indicates that TLR3 may have evolved to permit cross-priming of CTLs against viruses that do not directly infect dendedritic cells.
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Dendritic Cell-Derived Exosomes Need To Activate Both T and B Cells To Induce Antitumor Immunity
TL;DR: Proper activation of CD4+ T and B cells needs to be considered when designing cancer vaccines to ensure full potential of the treatment.
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Exosomes from breast milk inhibit HIV-1 infection of dendritic cells and subsequent viral transfer to CD4+ T cells.
Tanja I. Näslund,Dominic Paquin-Proulx,Patricia Torregrosa Paredes,Helen Vallhov,Johan K. Sandberg,Susanne Gabrielsson +5 more
TL;DR: It is proposed that milk exosomes act as a novel protective factor against vertical transmission of HIV-1 by competing with HIV- 1 for binding to DC-SIGN on MDDCs.
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Synergistic induction of adaptive antitumor immunity by codelivery of antigen with α-galactosylceramide on exosomes.
Ulf Gehrmann,Stefanie Hiltbrunner,Anna-Maria Georgoudaki,Mikael C. I. Karlsson,Tanja I. Näslund,Susanne Gabrielsson +5 more
TL;DR: Findings show that exosomes loaded with protein antigen and αGC will activate adaptive immunity in the absence of triggering iNKT-cell anergy, supporting their application in the design of a broad variety of cancer immunotherapy trials.