F
Friedrich Koch-Nolte
Researcher at University of Hamburg
Publications - 243
Citations - 11797
Friedrich Koch-Nolte is an academic researcher from University of Hamburg. The author has contributed to research in topics: NAD+ kinase & Gene. The author has an hindex of 51, co-authored 224 publications receiving 9867 citations. Previous affiliations of Friedrich Koch-Nolte include French Institute of Health and Medical Research & University of Rouen.
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Journal ArticleDOI
Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of human ARH3, the first eukaryotic protein-ADP-ribosylhydrolase.
Stefan Kernstock,Friedrich Koch-Nolte,Jochen Mueller-Dieckmann,Manfred S. Weiss,Christoph Mueller-Dieckmann +4 more
TL;DR: Human ADP-ribosylhydrolase 3, consisting of 347 amino-acid residues, has been cloned and heterologously expressed in Escherichia coli, purified and crystallized in two different space groups.
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Quantitative magnetic resonance imaging of enzyme activity on the cell surface: in vitro and in vivo monitoring of ADP-ribosyltransferase 2 on T cells.
Peter Bannas,Oliver Graumann,Philipp Balcerak,Kersten Peldschus,Michael G. Kaul,Heinrich Hohenberg,Friedrich Haag,Gerhard Adam,Harald Ittrich,Friedrich Koch-Nolte +9 more
TL;DR: Quantitative R2 and R2* mapping enable noninvasive determination of enzymatic activity on T cells and holds promise for characterization of inflammatory sites in vivo by MRI.
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Astrocytes and Microglia Are Resistant to NAD+-Mediated Cell Death Along the ARTC2/P2X7 Axis.
Björn Rissiek,Joschi Stabernack,Maike Cordes,Yinghui Duan,Sarah Behr,Stephan Menzel,Tim Magnus,Friedrich Koch-Nolte +7 more
TL;DR: It is found that astrocytes and microglia strongly upregulate cell surface levels of ARTC2.1 and ADP-ribosylation of cell surface proteins in response to treatment with lipopolysaccharide and the mitogen-activated protein kinase kinase 1 and 2 inhibitor U0126, but do not respond to extracellular NAD+ with P2X7 activation and induction of cell death.
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P2X7-mediated ATP secretion is accompanied by depletion of cytosolic ATP
Bjarne Johnsen,Klaus Eric Kaschubowski,Sorush Nader,Enja Schneider,Jan-Andrei Nicola,Ralf Fliegert,Insa M. A. Wolf,Andreas H. Guse,Viacheslav O. Nikolaev,Friedrich Koch-Nolte,Friedrich Haag +10 more
TL;DR: The potential of ATP sensors as tools to study regulated ATP release by other cell types under other conditions is demonstrated, using genetically encoded FRET-based ATP sensors targeted to the cytosol to image P2X7-mediated changes in the distribution of ATP in 3T3 fibroblasts co-expressing P2 X7 and ARTC2 and in Yac-1 cells.
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FK778 in Experimental Xenotransplantation: A Detailed Analysis of Drug Efficacy
Sonja Schrepfer,Tobias Deuse,Friedrich Koch-Nolte,Thorsten Krieger,Munif Haddad,Hansjörg Schäfer,Marc P. Pelletier,Robert C. Robbins,Hermann Reichenspurner +8 more
TL;DR: FK778 mildly interfered with hyperacute rejection and markedly suppressed acute humoral and cellular aortic xenograft rejection, however, T-cell-dependent host responses were most potently suppressed by tacrolimus, and the overall efficacy of FK778 was similar to that of sirolimus.