F
Friedrich Koch-Nolte
Researcher at University of Hamburg
Publications - 243
Citations - 11797
Friedrich Koch-Nolte is an academic researcher from University of Hamburg. The author has contributed to research in topics: NAD+ kinase & Gene. The author has an hindex of 51, co-authored 224 publications receiving 9867 citations. Previous affiliations of Friedrich Koch-Nolte include French Institute of Health and Medical Research & University of Rouen.
Papers
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Journal ArticleDOI
Proteomic Characterization of the Heart and Skeletal Muscle Reveals Widespread Arginine ADP-Ribosylation by the ARTC1 Ectoenzyme.
Mario Leutert,Stephan Menzel,Rickmer Braren,Björn Rissiek,Ann-Katrin Hopp,Kathrin Nowak,Lavinia Bisceglie,Peter Gehrig,Hui Li,Anna Zolkiewska,Friedrich Koch-Nolte,Michael O. Hottiger +11 more
TL;DR: Validation of hemopexin (HPX) as a ARTC1-target protein confirmed the functional importance of AR TC1-mediated extracellular arginine ADP-ribosylation at the systems level.
Journal ArticleDOI
ADP-ribosylation of membrane proteins: unveiling the secrets of a crucial regulatory mechanism in mammalian cells.
Friedrich Koch-Nolte,Sahil Adriouch,Peter Bannas,Christian Krebs,Felix Scheuplein,Michel Seman,Friedrich Haag +6 more
TL;DR: It is proposed that ART2‐catalyzed ADP‐ribosylation of P2X7 represents the paradigm of a regulatory mechanism by which ART‐expressing cells can sense and respond to the release of NAD from damaged cells.
Journal ArticleDOI
Long-term CD38 saturation by daratumumab interferes with diagnostic myeloma cell detection.
Anna Oberle,Anna Brandt,Malik Alawi,Claudia Langebrake,Snjezana Janjetovic,Christine Wolschke,Kerstin Schütze,Peter Bannas,Nicolaus Kröger,Friedrich Koch-Nolte,Carsten Bokemeyer,Mascha Binder +11 more
TL;DR: In vitro and in vivo data are presented illustrating that interference of daratumumab with diagnostic CD38 antibodies in flow cytometry represents another practical issue relevant for the management of patients with multiple myeloma who have received CD38-directed treatment.
Book ChapterDOI
ADP-ribosylation of P2X7: a matter of life and death for regulatory T cells and natural killer T cells.
TL;DR: The recent discoveries on the in vivo role of the ARTC2.2/P2X7 pathway triggered by the endogenous release of extracellular NAD(+), the relative sensitivity of lymphocytes subsets to this regulatory pathway and its pharmacological manipulation using camelid-derived ARTC 2.2-blocking nanobodies are highlighted.
Journal ArticleDOI
CD39 is upregulated during activation of mouse and human T cells and attenuates the immune response to Listeria monocytogenes
Friederike Raczkowski,Anne Rissiek,Isabell Ricklefs,Kirsten Heiss,Valéa Schumacher,Kira Wundenberg,Friedrich Haag,Friedrich Koch-Nolte,Eva Tolosa,Hans-Willi Mittrücker +9 more
TL;DR: It is demonstrated that CD39 is upregulated on conventional CD4+ and CD8+ T cells at sites of acute infection and inflammation, and thatCD39 dampens responses to bacterial infection.