F
Friedrich Koch-Nolte
Researcher at University of Hamburg
Publications - 243
Citations - 11797
Friedrich Koch-Nolte is an academic researcher from University of Hamburg. The author has contributed to research in topics: NAD+ kinase & Gene. The author has an hindex of 51, co-authored 224 publications receiving 9867 citations. Previous affiliations of Friedrich Koch-Nolte include French Institute of Health and Medical Research & University of Rouen.
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Journal ArticleDOI
Half-Life Extended Nanobody-Based CD38-Specific Bispecific Killercell Engagers Induce Killing of Multiple Myeloma Cells
Julia Hambach,William Fumey,Tobias Stähler,Anna Gebhardt,Gerhard Adam,Katja Weisel,Friedrich Koch-Nolte,Peter Bannas +7 more
TL;DR: The results demonstrate the efficacy of CD38-specific HLE-nano-BiKEs in vitro and ex vivo, warranting further preclinical evaluation in vivo of their therapeutic potential for the treatment of multiple myeloma.
Journal ArticleDOI
T-cell survival regulator LKLF is not involved in inappropriate apoptosis of diabetes-prone BBDP rat T cells.
TL;DR: The LKLF gene is not defective in dpBB rats and that its expression is not compromised by the lyp mutation, which has recently been identified as immune‐associated nucleotide 4 (ian4).
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A Methodological Approach Using rAAV Vectors Encoding Nanobody-Based Biologics to Evaluate ARTC2.2 and P2X7 In Vivo.
Henri Gondé,Mélanie Demeules,Romain Hardet,Allan Scarpitta,Marten Junge,Carolina Pinto-Espinoza,Rémi Varin,Friedrich Koch-Nolte,Olivier Boyer,Sahil Adriouch +9 more
TL;DR: In this article, an experimental approach using intramuscular injection of recombinant AAV vectors (rAAV) encoding nanobody-based biologics targeting ARTC2.2 or P2X7 was presented.
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Mouse CD38-Specific Heavy Chain Antibodies Inhibit CD38 GDPR-Cyclase Activity and Mediate Cytotoxicity Against Tumor Cells.
Natalie Baum,Marie Eggers,Julia Koenigsdorf,Stephan Menzel,Julia Hambach,Tobias Staehler,Ralf Fliegert,Frederike Kulow,Gerhard Adam,Friedrich Haag,Peter Bannas,Friedrich Koch-Nolte +11 more
TL;DR: In this article, the authors used phage display technology to isolate 13 mouse CD38-specific nanobodies from immunized llamas and produced these as recombinant chimeric mouse IgG2a heavy chain antibodies (hcAbs).
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The P2X7 ion channel is dispensable for energy and metabolic homeostasis of white and brown adipose tissues.
Tian Tian,Markus Heine,Ioannis Evangelakos,Michelle Y. Jaeckstein,Nicola Schaltenberg,Tobias Stähler,Friedrich Koch-Nolte,Manju Kumari,Joerg Heeren +8 more
TL;DR: Comparative studies show that P2X7 plays only a minor role in inflammatory and thermogenic effects of white and brown adipose tissue even on the BALB/c background, and deficiency of P2rx7 is dispensable for energy expenditure at thermoneutral and acute cold exposure conditions.