F
Friedrich Koch-Nolte
Researcher at University of Hamburg
Publications - 243
Citations - 11797
Friedrich Koch-Nolte is an academic researcher from University of Hamburg. The author has contributed to research in topics: NAD+ kinase & Gene. The author has an hindex of 51, co-authored 224 publications receiving 9867 citations. Previous affiliations of Friedrich Koch-Nolte include French Institute of Health and Medical Research & University of Rouen.
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Journal ArticleDOI
Extracellular NAD+ shapes the Foxp3+ regulatory T cell compartment through the ART2–P2X7 pathway
Sandra Hubert,Björn Rissiek,Katjana Klages,Jochen Huehn,Tim Sparwasser,Friedrich Haag,Friedrich Koch-Nolte,Olivier Boyer,Michel Seman,Sahil Adriouch +9 more
TL;DR: Extracellular NAD+ affects the survival and function of Regulatory T cells, and NAD-mediated depletion of regulatory T cells promotes anti-tumor responses in mice.
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Auto-aggressive CXCR6 + CD8 T cells cause liver immune pathology in NASH
Michael Dudek,Dominik Pfister,Sainitin Donakonda,Pamela Filpe,Annika Schneider,Melanie Laschinger,Daniel Hartmann,Norbert Hüser,Philippa Meiser,Felix Bayerl,Donato Inverso,Donato Inverso,Jennifer Wigger,Marcial Sebode,Rupert Öllinger,Roland Rad,Silke Hegenbarth,Martina Anton,Adrien Guillot,Andrew P. Bowman,Danijela Heide,Florian Müller,Pierluigi Ramadori,Valentina Leone,Cristina García-Cáceres,Tim Gruber,Gabriel Seifert,Agnieszka M. Kabat,Jan-Philipp Mallm,Simon Reider,Maria Effenberger,Susanne Roth,Adrian T. Billeter,Beat P. Müller-Stich,Edward J. Pearce,Friedrich Koch-Nolte,Rafael Käser,Herbert Tilg,Robert Thimme,Tobias Boettler,Frank Tacke,Jean-François Dufour,Dirk Haller,Peter J. Murray,Peter J. Murray,Ron M. A. Heeren,Dietmar Zehn,Jan P. Böttcher,Mathias Heikenwalder,Percy A. Knolle +49 more
TL;DR: In this paper, a preclinical mouse model that displays key features of human NASH (hereafter, NASH mice), was used to detect the hepatic accumulation of CD8 T cells with phenotypes that combined tissue residency (CXCR6) with effector (granzyme) and exhaustion (PD1) characteristics.
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A PKR-like eukaryotic initiation factor 2α kinase from zebrafish contains Z-DNA binding domains instead of dsRNA binding domains
Stefan Rothenburg,Nikolaus Deigendesch,Katharina Dittmar,Friedrich Koch-Nolte,Friedrich Haag,Ky Lowenhaupt,Alexander Rich,Alexander Rich +7 more
TL;DR: This previously undescribed kinase, designated PKZ (protein kinase containing Z-DNA binding domains), is transcribed constitutively at low levels and is highly induced after injection of poly(inosinic)-poly(cytidylic) acid, which simulates viral infection.
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Purine Release, Metabolism, and Signaling in the Inflammatory Response.
TL;DR: This review focuses on recent advances in understanding of purine release mechanisms, ectoenzymes that metabolize purines (CD38, CD39, CD73, ENPP1, and ENPP2/autotaxin), and signaling by key P2 purinergic receptors (P2X7, P2y2, and P2Y12).
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Extracellular NAD and ATP: Partners in immune cell modulation.
Friedrich Haag,Sahil Adriouch,Anette Braß,Caroline Jung,Sina Möller,Felix Scheuplein,Peter Bannas,Michel Seman,Friedrich Koch-Nolte +8 more
TL;DR: P2X7-mediated NAD-induced cell death (NICD) specifically targets this cell population and may inhibit bystander activation of unprimed T cells, reducing the risk of autoimmunity and augment an immune response.