F
Friedrich Koch-Nolte
Researcher at University of Hamburg
Publications - 243
Citations - 11797
Friedrich Koch-Nolte is an academic researcher from University of Hamburg. The author has contributed to research in topics: NAD+ kinase & Gene. The author has an hindex of 51, co-authored 224 publications receiving 9867 citations. Previous affiliations of Friedrich Koch-Nolte include French Institute of Health and Medical Research & University of Rouen.
Papers
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Journal ArticleDOI
Selection of nanobodies that block the enzymatic and cytotoxic activities of the binary Clostridium difficile toxin CDT.
Mandy Unger,Anna Marei Eichhoff,Lucas Schumacher,Moritz Strysio,Stephan Menzel,Carsten Schwan,Vanina Alzogaray,Vanesa Zylberman,Michel Seman,Johanna M. Brandner,Holger Rohde,Kai Zhu,Friedrich Haag,Hans-Willi Mittrücker,Fernando Alberto Goldbaum,Klaus Aktories,Friedrich Koch-Nolte +16 more
TL;DR: The generation of functional nanobodies against the enzymatic CDTa and the heptameric receptor binding subunit CDTb hold promise as new tools for research, diagnosis and therapy of C. difficile associated disease.
Journal ArticleDOI
Alternative Splicing of the N-Terminal Cytosolic and Transmembrane Domains of P2X7 Controls Gating of the Ion Channel by ADP-Ribosylation
Nicole Schwarz,Laurent Drouot,Annette Nicke,Ralf Fliegert,Olivier Boyer,Andreas H. Guse,Friedrich Haag,Sahil Adriouch,Friedrich Koch-Nolte +8 more
TL;DR: In this paper, the authors compare the two splice variants of P2X7 with respect to their sensitivities to gating by ADP-ribosylation in transfected HEK cells.
Book ChapterDOI
Mono(Adp-Ribosyl)Transferases and Related Enzymes in Animal Tissues
TL;DR: In this paper, the authors review the relationship between eucaryotic mono-ADP-ribosyl transferases (mADPRTs) and other enzymes in terms of their structure, enzymatic properties and possible biological functions.
Book ChapterDOI
Sequence and structural links between distant ADP-ribosyltransferase families.
J F Bazan,Friedrich Koch-Nolte +1 more
TL;DR: Faint sequence resemblances that were earlier noticed among prokaryotic ADPRTs have now been securely extended by the structural concordance between toxin folds, and efforts in Palo Alto and Hamburg to explore these latter relationships are summarized.
Journal ArticleDOI
Extracellular NAD(+): a danger signal hindering regulatory T cells.
Sahil Adriouch,Sahil Adriouch,Friedrich Haag,Olivier Boyer,Olivier Boyer,Michel Seman,Friedrich Koch-Nolte +6 more
TL;DR: Extracellular NAD(+) stimulates immune responses by hindering regulatory T cells (Tregs), and could, therefore, represent the prototype of a new category of danger signals.