F
Friedrich Koch-Nolte
Researcher at University of Hamburg
Publications - 243
Citations - 11797
Friedrich Koch-Nolte is an academic researcher from University of Hamburg. The author has contributed to research in topics: NAD+ kinase & Gene. The author has an hindex of 51, co-authored 224 publications receiving 9867 citations. Previous affiliations of Friedrich Koch-Nolte include French Institute of Health and Medical Research & University of Rouen.
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Journal ArticleDOI
Novel biologics targeting the P2X7 ion channel
Friedrich Koch-Nolte,Anna Marei Eichhoff,Carolina Pinto-Espinoza,Nicole Schwarz,Tobias Schäfer,Stephan Menzel,Friedrich Haag,Mélanie Demeules,Henri Gondé,Sahil Adriouch,Sahil Adriouch +10 more
TL;DR: Targeting the P2X7 ion channel, a danger sensor for extracellular nucleotides, improves outcomes in models of inflammation, cancer, and brain-diseases, and AAVs may enable modulation of the function of P2x7-expressing immune cells via encoded transgenic RNA or proteins.
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Substrate binding and catalysis of ecto-ADP-ribosyltransferase 2.2 from rat.
TL;DR: The structures and mutant activities of ecto-ADP-ribosyltransferase 2.2 from rat and to its mutants E189I and E189A have been established, confirming that hydrolysis is the major function of this enzyme.
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Lipopolysaccharide, IFN-γ, and IFN-β Induce Expression of the Thiol-Sensitive ART2.1 Ecto-ADP-Ribosyltransferase in Murine Macrophages
TL;DR: It is reported that bone marrow-derived macrophages from BALB/c mice lack constitutive expression of any of the six murine ecto-ART subtypes, but selectively up-regulate ART2.1 in response to multiple proinflammatory mediators including agonists for TLR and type I and type II IFN.
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CD38-Specific Biparatopic Heavy Chain Antibodies Display Potent Complement-Dependent Cytotoxicity Against Multiple Myeloma Cells.
Kerstin Schütze,Katharina Petry,Julia Hambach,Niklas Schuster,William Fumey,Levin Schriewer,Jana Larissa Röckendorf,Stephan Menzel,Birte Albrecht,Friedrich Haag,Catelijne Stortelers,Peter Bannas,Friedrich Koch-Nolte +12 more
TL;DR: The CD38-specific biparatopic heavy chain antibodies described here represent potential new powerful therapeutics for treatment of multiple myeloma and underscore the advantage of nanobodies vs. pairs of VH and VL domains for constructing bispecific antibodies.
Journal Article
Structure of the gene encoding the rat T cell ecto-ADP-ribosyltransferase RT6.
TL;DR: An analysis of the rat RT6 gene is presented, providing a basis for studying the regulation of this gene in T cells of normal and diabetes-prone rats and is the first structural analysis of a mammalian mono-ADP-ribosyltransferase gene.