F
Friedrich Koch-Nolte
Researcher at University of Hamburg
Publications - 243
Citations - 11797
Friedrich Koch-Nolte is an academic researcher from University of Hamburg. The author has contributed to research in topics: NAD+ kinase & Gene. The author has an hindex of 51, co-authored 224 publications receiving 9867 citations. Previous affiliations of Friedrich Koch-Nolte include French Institute of Health and Medical Research & University of Rouen.
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Journal ArticleDOI
Assignment of the human RT6 gene to 11q13 by PCR screening of somatic cell hybrids and in situ hybridization.
Friedrich Koch-Nolte,Friedrich Haag,Maren Kühl,Veronica van Heyningen,Jan M.N. Hoovers,Karl-Heinz Grzeschik,Surjit Singh,Heinz-Günter Thiele +7 more
TL;DR: In the human, the RT6 locus is dissociated from the hemoglobin beta chain locus (HBB) and its neighboring conserved linkage group at 11p15, in contrast to the mouse, in which RT6 shows a tighter linkage to Hbb than to Tyr.
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P2X7 Receptors as a Therapeutic Target in Cerebrovascular Diseases
Abraham Cisneros-Mejorado,Alberto Pérez-Samartín,María Domercq,Rogelio O. Arellano,Miroslav Gottlieb,Friedrich Koch-Nolte,Carlos Matute +6 more
TL;DR: Current knowledge about the participation of key elements in the ATP-mediated deleterious effects in cerebrovascular diseases including pannexin-1 hemichannels, calcium homeostasis modulator-1 (CALHM1), purinergic P2X7 receptors, and other intermediaries of CNS injury downstream of ATP release are summarized.
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Blocking P2X7 by intracerebroventricular injection of P2X7-specific nanobodies reduces stroke lesions
Maximilian Wilmes,Carolina Pinto Espinoza,Peter Ludewig,Joschi Stabernack,Arthur Liesz,Annette Nicke,Mathias Gelderblom,Christian Gerloff,Simonetta Falzoni,Eva Tolosa,Francesco Di Virgilio,Björn Rissiek,Nikolaus Plesnilla,Friedrich Koch-Nolte,Tim Magnus +14 more
TL;DR: In this paper , the P2X7-specific nanobodies (nbs) have been used to effectively block the P 2X7 channel, which has been shown to reduce the severity of ischemic stroke.
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Sirolimus and FK778: a comparison of two anti‐proliferative immunosuppressants for prevention of experimental obliterative airway disease
Tobias Deuse,Sonja Schrepfer,Friedrich Koch-Nolte,Munif Haddad,Hansjörg Schäfer,Christian Detter,Hermann Reichenspurner +6 more
TL;DR: Both agents proved effective to prevent OAD development without preserving relevant amounts of epithelium and the anti‐proliferative potency on SMCs seems to be an especially important mechanism for FK778.
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FK778: New Cellular and Molecular Mechanisms of Action
TL;DR: FK778 directly reduced endothelial adhesion molecule up-regulation, inhibited lymphocyte activation, and attenuated lymphocyte-endothelium interactions, critical early steps in graft rejection, separate from the blockade of pyrimidine synthesis.