F
Fulvio Mavilio
Researcher at University of Modena and Reggio Emilia
Publications - 228
Citations - 20283
Fulvio Mavilio is an academic researcher from University of Modena and Reggio Emilia. The author has contributed to research in topics: Genetic enhancement & Viral vector. The author has an hindex of 68, co-authored 227 publications receiving 19200 citations. Previous affiliations of Fulvio Mavilio include Paris Descartes University & Vita-Salute San Raffaele University.
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Journal ArticleDOI
Activation of four homeobox gene clusters in human embryonal carcinoma cells induced to differentiate by retinoic acid
TL;DR: The data indicate that homeobox-gene activation specifically accompanies RA-induced differentiation of NT2/D1 cells, thereby providing an excellent model for studying the molecular basis of homeOBox-Gene regulation and the possible role of the homeobbox in cell differentiation.
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Lentiviral vector integration in the human genome induces alternative splicing and generates aberrant transcripts
Arianna Moiani,Ylenia Paleari,Daniela Sartori,Riccardo Mezzadra,Annarita Miccio,Claudia Cattoglio,Fabienne Cocchiarella,Maria Rosa Lidonnici,Giuliana Ferrari,Fulvio Mavilio +9 more
TL;DR: A limited set of cryptic splice sites caused the majority of aberrant splicing events, providing a strategy for recoding lentiviral vector backbones and transgenes to reduce their potential posttranscriptional genotoxicity.
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Gene therapy prolongs survival and restores function in murine and canine models of myotubular myopathy
Martin K. Childers,R. Joubert,Karine Poulard,Christelle Moal,Robert W. Grange,Jonathan Doering,Michael W. Lawlor,Michael W. Lawlor,Branden E. Rider,T. Jamet,Nathalie Daniele,Samia Martin,Christel Rivière,Thomas Soker,C. Hammer,Laetitia van Wittenberghe,Mandy Lockard,Xuan Guan,Melissa A. Goddard,Erin Mitchell,Jane Barber,J. Koudy Williams,David L. Mack,Mark E. Furth,Alban Vignaud,Carole Masurier,Fulvio Mavilio,Philippe Moullier,Philippe Moullier,Alan H. Beggs,Anna Buj-Bello +30 more
TL;DR: The results demonstrate the efficacy of gene replacement therapy for myotubular myopathy in animal models and pave the way to a clinical trial in patients, and provide proof of concept for future clinical trials in XLMTM patients.
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Specificity of HOX protein function depends on DNA-protein and protein-protein interactions, both mediated by the homeo domain.
TL;DR: Affinity chromatography experiments show that the homeo domain amino terminus/helix 1 region is able to mediate direct interactions between HOX proteins in solution, which indicates that specificity of HOX protein function in vivo depends on both DNA-protein and protein-protein interactions, mediated by the same sub region of theHomeo domain.
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An in vivo model of somatic cell gene therapy for human severe combined immunodeficiency
Giuliana Ferrari,Silvano Rossini,Raffaella Giavazzi,Daniela Maggioni,Nadia Nobili,Monica Soldati,Grace Ungers,Fulvio Mavilio,Eli Gilboa,Claudio Bordignon +9 more
TL;DR: Retroviral vector gene transfer is necessary and sufficient for development of specific immune functions in vivo and has therapeutic potential to correct this lethal immunodeficiency.