M
Masato Tanaka
Researcher at Tokyo University of Pharmacy and Life Sciences
Publications - 139
Citations - 17877
Masato Tanaka is an academic researcher from Tokyo University of Pharmacy and Life Sciences. The author has contributed to research in topics: Apoptosis & Fas ligand. The author has an hindex of 51, co-authored 127 publications receiving 16465 citations. Previous affiliations of Masato Tanaka include National Institutes of Health & Osaka University.
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Journal ArticleDOI
Tissue-Resident Macrophages Self-Maintain Locally throughout Adult Life with Minimal Contribution from Circulating Monocytes
Daigo Hashimoto,Andrew Chow,Andrew Chow,Clara Noizat,Clara Noizat,Pearline Teo,Mary Beth Beasley,Marylene Leboeuf,Christian Becker,Peter See,Jeremy Price,Daniel Lucas,Melanie Greter,Melanie Greter,Arthur Mortha,Scott W. Boyer,E. Camilla Forsberg,Masato Tanaka,Nico van Rooijen,Adolfo García-Sastre,E. Richard Stanley,Florent Ginhoux,Paul S. Frenette,Miriam Merad +23 more
TL;DR: Results indicate that tissue-resident macrophages and circulating monocytes should be classified as mononuclear phagocyte lineages that are independently maintained in the steady state.
Journal ArticleDOI
Generalized lymphoproliferative disease in mice, caused by a point mutation in the fas ligand
Tomohiro Takahashi,Masato Tanaka,Camllynn I. Brannan,Nancy A. Jenkins,Neal G. Copeland,Takashi Suda,Shigekazu Nagata +6 more
TL;DR: The results indicate that lpr and gld are mutations in Fas and Fasl, respectively, and suggest important roles of the Fas system in development of T cells as well as cytotoxic T lymphocyte-mediated cytotoxicity.
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Identification of a factor that links apoptotic cells to phagocytes
Rikinari Hanayama,Masato Tanaka,Keiko Miwa,Azusa Shinohara,Akihiro Iwamatsu,Shigekazu Nagata +5 more
TL;DR: Results indicate that milk fat globule-EGF-factor 8 secreted from activated macrophages binds to apoptotic cells, and brings them to phagocytes for engulfment.
Journal ArticleDOI
Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient mice.
Rikinari Hanayama,Masato Tanaka,Kay Miyasaka,Katsuyuki Aozasa,Masato Koike,Yasuo Uchiyama,Shigekazu Nagata +6 more
TL;DR: It is reported that tingible body macrophages in the germinal centers of the spleen and lymph nodes strongly express MFG-E8, a protein that binds to apoptotic cells by recognizing phosphatidylserine and that enhances the engulfment of apoptosis cells by macrophage.
Journal ArticleDOI
Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche
Andrew Chow,Daniel Lucas,Daniel Lucas,Andrés Hidalgo,Andrés Hidalgo,Simón Méndez-Ferrer,Simón Méndez-Ferrer,Daigo Hashimoto,Christoph Scheiermann,Christoph Scheiermann,Michela Battista,Marylene Leboeuf,Colette Prophete,Colette Prophete,Nico van Rooijen,Masato Tanaka,Miriam Merad,Paul S. Frenette,Paul S. Frenette +18 more
TL;DR: Results highlight two antagonistic, tightly balanced pathways that regulate maintenance of HSCs/progenitors in the niche during homeostasis, in which MΦ cross talk with the Nestin+ niche cell promotes retention, and in contrast, SNS signals enhance egress.