F
Fung Ki Wong
Researcher at Karolinska Institutet
Publications - 17
Citations - 945
Fung Ki Wong is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: MEN1 & Multiple endocrine neoplasia. The author has an hindex of 13, co-authored 17 publications receiving 929 citations.
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Journal ArticleDOI
Mutation analysis of the MEN1 gene in multiple endocrine neoplasia type 1, familial acromegaly and familial isolated hyperparathyroidism
Bin Tean Teh,Soili Kytölä,Filip Farnebo,L. Bergman,Fung Ki Wong,Günther Weber,Nicholas K. Hayward,Catharina Larsson,Britt Skogseid,Albert Beckers,Catherine M. Phelan,Matthew S. Edwards,M. Epstein,Frank P. Alford,D Hurley,Sean M. Grimmond,Ginters Silins,Marilyn K. Walters,Christine Stewart,John Cardinal,Shideh Khodaei,Fabienne Parente,L. Tranebjærg,R. Jorde,J. Menon,A. Khir,T. T. Tan,Siew Pheng Chan,A. Zaini,B. A. K. Khalid,Kerstin Sandelin,Norman W. Thompson,M. L. Brandi,M. Warth,John L. Stock,J. Leisti,David Cameron,Joseph J. Shepherd,Kjell Öberg,Magnus Nordenskjöld,Pasi I. Salmela +40 more
TL;DR: No mutation was found in any of the acromegaly and small FIHP families, suggesting that genetic defects other than the MEN1 gene might be involved and that additional such families need to be analyzed.
Journal ArticleDOI
Familial isolated hyperparathyroidism maps to the hyperparathyroidism-jaw tumor locus in 1q21-q32 in a subset of families.
Bin Tean Teh,Filip Farnebo,Stephen M. Twigg,Anders Höög,Soili Kytölä,Eeva Korpi-Hyövälti,Fung Ki Wong,Jörgen Nordenström,Lars Grimelius,Kerstin Sandelin,Bruce G. Robinson,Lars-Ove Farnebo,Catharina Larsson +12 more
TL;DR: It is found that the hyperparathyroidism traits in a subset of FIHP families are linked to the 1q21-32 markers in the HRPT2 region and that the gene involved is a tumor suppressor gene.
Journal ArticleDOI
A genotypic and histopathological study of a large Dutch kindred with hyperparathyroidism-jaw tumor syndrome.
Carola J. Haven,Fung Ki Wong,Eveline W. C. M. van Dam,Rob B. van der Luijt,Christi J. van Asperen,Joke Jansen,Carla Rosenberg,Mireille J. De Wit,Janine Roijers,Jo W.M. Höppener,Cornelis J.M. Lips,Catharina Larsson,Bin Tean Teh,Hans Morreau +13 more
TL;DR: A family with hyperparathyroidism linked to chromosome 1q, and exhibiting several types of renal and endocrine tumors that have not been previously described is reported.
Journal ArticleDOI
Alternative genetic pathways in parathyroid tumorigenesis.
Filip Farnebo,Soili Kytölä,Bin Tean Teh,Trisha Dwight,Fung Ki Wong,Anders Höög,Maria Elvius,Wassif S. Wassif,Norman W. Thompson,Lars-Ove Farnebo,Kerstin Sandelin,Catharina Larsson +11 more
TL;DR: Numerical copy number alterations were frequently detected in sporadic and irradiation-associated parathyroid adenomas, although these tumors are benign, and suggests that inactivation of the MEN1 gene is an important genetic alteration involved in the development ofParathyroid tumors in postirradiation patients.
Journal ArticleDOI
Familial isolated hyperparathyroidism as a variant of multiple endocrine neoplasia type 1 in a large Danish pedigree.
TL;DR: It is concluded that some of the familial isolated primary hyperparathyroidism families constitute a milder variant of MEN 1, which is associated with a functionally milder missense mutation.