G
Günther Weber
Researcher at François Rabelais University
Publications - 77
Citations - 4483
Günther Weber is an academic researcher from François Rabelais University. The author has contributed to research in topics: Gene & MEN1. The author has an hindex of 30, co-authored 77 publications receiving 4279 citations. Previous affiliations of Günther Weber include French Institute of Health and Medical Research & Karolinska Institutet.
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Journal ArticleDOI
The cathelicidin anti-microbial peptide LL-37 is involved in re-epithelialization of human skin wounds and is lacking in chronic ulcer epithelium.
Johan Heilborn,Margareta Frohm Nilsson,Gunnar Kratz,Günther Weber,Ole E. Sørensen,Niels Borregaard,Mona Ståhle-Bäckdahl +6 more
TL;DR: It is suggested that, in addition to being an anti-microbial peptide, LL-37 also plays a part in wound closure and that its reduction in chronic wounds impairs re-epithelialization and may contribute to their failure to heal.
Journal ArticleDOI
Identification of the Multiple Endocrine Neoplasia Type 1 (MEN1) Gene. The European Consortium on MEN1
Irma Lemmens,Wim J.M. Van de Ven,Koen Kas,Chang X. Zhang,Sophie Giraud,Virginie Wautot,Nathalie Buisson,Ko De Witte,Janine Salandre,Gilbert M. Lenoir,Michel Pugeat,Alain Calender,Fabienne Parente,Danielle Quincey,Patrick Gaudray,Mireille J. De Wit,Cornelis J.M. Lips,Jo W.M. Höppener,Shideh Khodaei,Abby L. Grant,Günther Weber,Soili Kytölä,Bin Tean Teh,Filip Farnebo,Catherine M. Phelan,Nicholas K. Hayward,Catharina Larsson,Anna A.J. Pannett,Simon A. Forbes,J. H. Duncan Bassett,Rajesh V. Thakker +30 more
TL;DR: Mutational analysis of SCG2 in 10 unrelated MEN1 families identified one polymorphism and nine different heterozygous mutations that segregated with the disease, hence providing an independent confirmation for the identification of the MEN1 gene.
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The Human Cationic Antimicrobial Protein (hCAP18), a Peptide Antibiotic, Is Widely Expressed in Human Squamous Epithelia and Colocalizes with Interleukin-6
Margareta Frohm Nilsson,Bengt Sandstedt,Ole E. Sørensen,Günther Weber,Niels Borregaard,Mona Ståhle-Bäckdahl +5 more
TL;DR: The finding that h CAP18 is widely produced in squamous epithelia suggests a role for this peptide in epithelial antimicrobial defense, and colocalization with interleukin-6 indicates a potential local mechanism for the upregulation of hCAP18 at the epithelial surfaces.
Journal ArticleDOI
Vitamin D induces the antimicrobial protein hCAP18 in human skin.
Günther Weber,Johan Heilborn,Clara I. Chamorro Jimenez,Anna Hammarsjö,Hans Törmä,Mona Ståhle +5 more
Journal ArticleDOI
Mutation analysis of the MEN1 gene in multiple endocrine neoplasia type 1, familial acromegaly and familial isolated hyperparathyroidism
Bin Tean Teh,Soili Kytölä,Filip Farnebo,L. Bergman,Fung Ki Wong,Günther Weber,Nicholas K. Hayward,Catharina Larsson,Britt Skogseid,Albert Beckers,Catherine M. Phelan,Matthew S. Edwards,M. Epstein,Frank P. Alford,D Hurley,Sean M. Grimmond,Ginters Silins,Marilyn K. Walters,Christine Stewart,John Cardinal,Shideh Khodaei,Fabienne Parente,L. Tranebjærg,R. Jorde,J. Menon,A. Khir,T. T. Tan,Siew Pheng Chan,A. Zaini,B. A. K. Khalid,Kerstin Sandelin,Norman W. Thompson,M. L. Brandi,M. Warth,John L. Stock,J. Leisti,David Cameron,Joseph J. Shepherd,Kjell Öberg,Magnus Nordenskjöld,Pasi I. Salmela +40 more
TL;DR: No mutation was found in any of the acromegaly and small FIHP families, suggesting that genetic defects other than the MEN1 gene might be involved and that additional such families need to be analyzed.