G
G. M. Besser
Researcher at Tulane University
Publications - 8
Citations - 636
G. M. Besser is an academic researcher from Tulane University. The author has contributed to research in topics: Hormone & Endocrine gland. The author has an hindex of 7, co-authored 8 publications receiving 634 citations. Previous affiliations of G. M. Besser include Barts Health NHS Trust & St Bartholomew's Hospital.
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Journal ArticleDOI
Action of growth-hormone-release inhibitory hormone in healthy men and in acromegaly
R. Hall,Andrew V. Schally,D.C. Evered,Abba J. Kastin,C. H. Mortimer,W. M. G. Tunbridge,G. M. Besser,David H. Coy,D.J Goldie,McNeilly As,C Phenekos,D Weightman +11 more
TL;DR: The synthetic growth-hormone-release inhibitory hormone inhibits G.R.R.-I.H. response to insulin-induced hypoglycaemia without affecting the prolactin or corticosteroid responses, but the effects are short-lived.
Journal ArticleDOI
New hypothalamic hormone, corticotropin-releasing factor, specifically stimulates the release of adrenocorticotropic hormone and cortisol in man
A. Grossman,A. Grossman,L. Perry,L. Perry,Andrew V. Schally,Andrew V. Schally,Lesley H. Rees,Lesley H. Rees,A. C. Nieuwenhuyzen Kruseman,A. C. Nieuwenhuyzen Kruseman,Susan Tomlin,Susan Tomlin,David H. Coy,David H. Coy,Ana Maria Comaru-Schally,Ana Maria Comaru-Schally,G. M. Besser,G. M. Besser +17 more
TL;DR: A synthetic preparation of the 41-aminoacid-residue peptide recently isolated from ovine hypothalami and characterised corticotropin-releasing factor (CRF) suggests that it, or a related peptide, may be a CRF in man, and it may provide the basis for a new clinical test of pituitary ACTH reserve.
Journal ArticleDOI
Growth-hormone-releasing factor in growth hormone deficiency: demonstration of a hypothalamic defect in growth hormone release
A. Grossman,A. Grossman,J. A H Wass,J. A H Wass,J. Sueiras-Diaz,J. Sueiras-Diaz,M.O. Savage,M.O. Savage,N. Lytras,N. Lytras,David H. Coy,David H. Coy,G. M. Besser,G. M. Besser +13 more
TL;DR: Four patients with hypothalamic tumours or idiopathic growth hormone deficiency, who were GH deficient by conventional criteria, responded to 200 micrograms synthetic hpGRF-40 with a clear rise in circulating GH.
Journal ArticleDOI
Actions of growth hormone-release inhibiting hormone (somatostatin) on the renin aldosterone system.
A. Gomez-Pan,M. H. Snow,D.A. Piercy,V. Robson,R. Wilkinson,R. Hall,D.C. Evered,G. M. Besser,Andrew V. Schally,Abba J. Kastin,David H. Coy +10 more
TL;DR: Administration of growth hormone-release inhibiting hormone (GH-RIH, somatostatin) as a 90 minute infusion to 3 healthy young men under conditons of active renin secretion caused a mean 30% fall in plasma renin activity, which returned to basal levels immediately after stopping the GH- RIH infusion.
Journal ArticleDOI
Hypothalamic hormone interaction in acromegaly.
A. Gomez-Pan,A. Gomez-Pan,A. Gomez-Pan,W. M. G. Tunbridge,W. M. G. Tunbridge,W. M. G. Tunbridge,Anne Duns,Anne Duns,Anne Duns,R. Hall,R. Hall,R. Hall,G. M. Besser,G. M. Besser,G. M. Besser,David H. Coy,David H. Coy,David H. Coy,Andrew V. Schally,Andrew V. Schally,Andrew V. Schally,Abba J. Kastin,Abba J. Kastin,Abba J. Kastin +23 more
TL;DR: The growth hormone response to the administration of the currently available synthetic hypothalamic hormones was assessed in eleven patients with acromegaly and the GH response was shown to be unrelated to the thyrotrophin response to TRH.