D
David H. Coy
Researcher at Tulane University
Publications - 625
Citations - 26046
David H. Coy is an academic researcher from Tulane University. The author has contributed to research in topics: Somatostatin & Receptor. The author has an hindex of 74, co-authored 623 publications receiving 25318 citations. Previous affiliations of David H. Coy include University of Shizuoka & Mexican Social Security Institute.
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Journal ArticleDOI
Isolation of a novel 38 residue-hypothalamic polypeptide which stimulates adenylate cyclase in pituitary cells
Atsuro Miyata,Akira Arimura,Raymond R. Dahl,Naoto Minamino,Akira Uehara,Lun Jiang,M.D. Culler,David H. Coy +7 more
TL;DR: A novel neuropeptide which stimulates adenylate cyclase in rat anterior pituitary cell cultures was isolated from ovine hypothalamic tissues and increased release of growth hormone, prolactin, corticotropin and luteinizing hormone from superfused rat pituitaries at as small a dose as 10(-10)M) or 10(-9)M (LH).
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Tissue distribution of PACAP as determined by RIA: highly abundant in the rat brain and testes.
TL;DR: The highest concentration of radioimmunoassayable PACAP38 was found in the hypothalamus, but other brain regions also contained considerable amounts ofPACAP38, and the total amount of PACAP in both testes exceeded its content in the whole brain.
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Inhibition of gastrin and gastric-acid secretion by growth-hormone release-inhibiting hormone
Stephen R. Bloom,C. H. Mortimer,Michael O. Thorner,G.M. Besser,Reginald Hall,A. Gomez-Pan,V.M Roy,R C Russell,David H. Coy,A.T Kastin,Andrew V. Schally +10 more
TL;DR: The hypothalamic polypeptide growth-hormone release-inhibiting hormone (G.H.R.I.H.) inhibited gastrin release in all subjects studied and greatly lowered plasma-gastrin concentrations and almost totally suppressed gastric-acid production.
Journal Article
The antimicrobial peptides and their potential clinical applications
Jun Lei,Li Chun Sun,Li Chun Sun,Siyu Huang,Chenhong Zhu,Ping Li,Jun He,Vienna Mackey,David H. Coy,Quan Yong He +9 more
TL;DR: To open the clinical applications, it is necessary and important to develop the synthetic and long-lasting AMP analogs that overcome the disadvantages of their natural peptides and the potential problems for the drug candidates.
Journal ArticleDOI
Dynorphin Immunocytochemistry in the Rat Central Nervous System
Henry Khachaturian,Stanley J. Watson,Michael E. Lewis,David H. Coy,Avram Goldstein,Huda Akil +5 more
TL;DR: The results suggest that dynorphin occurs in neuronal systems that are immunocytochemically distinct from those containing other opioid peptides.