G
G S McKnight
Researcher at University of Washington
Publications - 41
Citations - 5502
G S McKnight is an academic researcher from University of Washington. The author has contributed to research in topics: Protein kinase A & Protein subunit. The author has an hindex of 37, co-authored 41 publications receiving 5430 citations.
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Journal ArticleDOI
Transcriptional regulation of the ovalbumin and conalbumin genes by steroid hormones in chick oviduct.
G S McKnight,Richard D. Palmiter +1 more
TL;DR: Relative rates of ovalbumin and conalbumin mRNA transcription were measured in isolated oviduct nuclei by allowing endogenous RNA polymerases to synthesize [32P]RNA that was then hybridized to immobilized recombinant DNA containing the respective gene sequences.
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Evidence for a second isoform of the catalytic subunit of cAMP-dependent protein kinase.
TL;DR: Determination of mRNA levels for C beta in various tissues shows that it is most highly expressed in brain although it is detectable in all tissues examined, and the presence of two genes coding for the C sub unit of cAMP-dependent protein kinase may explain past reports of heterogeneity in C subunit protein preparations.
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Isolation of cDNA clones coding for the catalytic subunit of mouse cAMP-dependent protein kinase
TL;DR: Southern blot analysis of total genomic DNA suggests that there is a single mouse gene coding for the C subunit of cAMP-dependent protein kinase, and enriched mRNA preparation was used to prepare and differentially screen a cDNA library.
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Novel (Rp)-cAMPS analogs as tools for inhibition of cAMP-kinase in cell culture. Basal cAMP-kinase activity modulates interleukin-1 beta action.
Bjørn Tore Gjertsen,Gunnar Mellgren,A.D. Otten,Erik Maronde,Hans G. Genieser,Bernd Jastorff,Olav Karsten Vintermyr,G S McKnight,Stein Ove Døskeland +8 more
TL;DR: It is concluded that the basal cAMP-kinase activity exerts a tonic inhibition of hepatocyte replication and can have a permissive role for the action of another (interleukin-1β) signaling pathway.
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Inhibition of intracellular cAMP-dependent protein kinase using mutant genes of the regulatory type I subunit.
TL;DR: Expression vectors were constructed that code for mutated forms of the regulatory type 1 subunit (RI) of cyclic AMP-dependent protein kinase that acted in a dominant fashion to cause a 20-400-fold inhibition of cAMP-dependentprotein kinase activation.