Gunnar Mellgren

TL;DR: The data indicate that the FTO allele associated with obesity represses mitochondrial thermogenesis in adipocyte precursor cells in a tissue-autonomous manner, and points to a pathway for adipocyte thermogenesis regulation involving ARID5B, rs1421085, IRX3, and IRX5, which, when manipulated, had pronounced pro-obesity and anti-ob obesity effects.

TL;DR: It is concluded that the basal cAMP-kinase activity exerts a tonic inhibition of hepatocyte replication and can have a permissive role for the action of another (interleukin-1β) signaling pathway.

TL;DR: Three new surface markers of white, beige, and brown fat cells are identified using a combination of in silico, in vitro, and in vivo methods to identify and target white and brown/beige adipocytes for therapeutic purposes.

TL;DR: It is proposed that therapeutic drug monitoring should be included in studies linking CYP2D6 and SULT1A1 genotypes to clinical outcome and may partly explain the wide inter-individual variations in the serum levels of tamoxifen and its metabolites.

TL;DR: It is shown that integrative computational analysis of phylogenetic conservation with a complexity assessment of co-occurring transcription factor binding sites (TFBS) can identify cis-regulatory variants and elucidate their mechanistic role in disease.