G
G. Woodward
Researcher at University of Bristol
Publications - 7
Citations - 1267
G. Woodward is an academic researcher from University of Bristol. The author has contributed to research in topics: DNA methylation & Offspring. The author has an hindex of 5, co-authored 7 publications receiving 1046 citations. Previous affiliations of G. Woodward include Norwegian University of Science and Technology & North Bristol NHS Trust.
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Journal ArticleDOI
Systematic identification of genetic influences on methylation across the human life course
Tom R. Gaunt,Hashem A. Shihab,Gibran Hemani,Josine L. Min,G. Woodward,Oliver Lyttleton,Jie Zheng,Aparna Duggirala,Wendy L. McArdle,Karen M Ho,Susan M. Ring,David M. Evans,David M. Evans,George Davey Smith,Caroline L Relton,Caroline L Relton +15 more
TL;DR: It is suggested that methylation may have a causal role consistent with an infinitesimal model in which many methylation sites each have a small influence, amounting to a large overall contribution.
Journal ArticleDOI
Prenatal exposure to maternal smoking and offspring DNA methylation across the lifecourse: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC)
Rebecca C Richmond,Andrew J Simpkin,G. Woodward,Tom R. Gaunt,Oliver Lyttleton,Wendy L. McArdle,Susan M. Ring,Andrew D A C Smith,Nicholas J. Timpson,Kate Tilling,George Davey Smith,Caroline L Relton +11 more
TL;DR: Investigation of associations between prenatal exposure to maternal smoking and offspring DNA methylation at multiple time points in approximately 800 mother–offspring pairs found that the major contribution to altered methylation was attributed to a critical window of in utero exposure.
Journal ArticleDOI
Data Resource Profile: Accessible Resource for Integrated Epigenomic Studies (ARIES)
Caroline L Relton,Tom R. Gaunt,Wendy L. McArdle,Karen M Ho,Aparna Duggirala,Hashem A. Shihab,G. Woodward,Oliver Lyttleton,David M. Evans,Wolf Reik,Yu-Lee Paul,Gabriella Ficz,Susan E. Ozanne,Anil Wipat,Keith Flanagan,Allyson L. Lister,Bastiaan T. Heijmans,Susan M. Ring,George Davey Smith +18 more
TL;DR: Data Resource Profile: Accessible Resource for Integrated Epigenomic Studies (ARIES) Caroline L Relton, Tom Gaunt, Wendy McArdle, Karen Ho, Aparna Duggirala, Hashem Shihab, Geoff Woodward, Oliver Lyttleton, David M Evans, Wolf Reik, Yu-Lee Paul, Gabriella Ficz, Susan E Ozanne and Susan M Ring.
Journal ArticleDOI
Prenatal exposure to maternal cigarette smoking and DNA methylation: epigenome-wide association in a discovery sample of adolescents and replication in an independent cohort at birth through 17 years of age.
Ken W. K. Lee,Rebecca C Richmond,Pingzhao Hu,Pingzhao Hu,Leon French,Jean Shin,Celine Bourdon,Eva Reischl,Melanie Waldenberger,Sonja Zeilinger,Tom R. Gaunt,Tom R. Gaunt,Wendy L. McArdle,Susan M. Ring,G. Woodward,Luigi Bouchard,Daniel Gaudet,George Davey Smith,Caroline L Relton,Tomáš Paus,Zdenka Pausova +20 more
TL;DR: The findings suggest that modifications of DNAm associated with prenatal maternal smoking may persist in exposed offspring for many years—at least until adolescence.
Journal ArticleDOI
Clinical genetic testing using a custom-designed steroid-resistant nephrotic syndrome gene panel: analysis and recommendations
Ethan S Sen,P. Dean,Laura Yarram-Smith,Agnieszka Bierzynska,G. Woodward,G. Woodward,C. Buxton,Gemma Dennis,Gavin I. Welsh,Maggie Williams,Moin A. Saleem,Moin A. Saleem +11 more
TL;DR: Gene panel testing provides a genetic diagnosis in a significant number of patients presenting with SRNS or suspected AS and should be undertaken at an early stage of the care pathway and include the ability to detect CNVs as an emerging mechanism for genes associated with this condition.