A
Andrew D A C Smith
Researcher at University of the West of England
Publications - 43
Citations - 1648
Andrew D A C Smith is an academic researcher from University of the West of England. The author has contributed to research in topics: dNaM & Population. The author has an hindex of 18, co-authored 43 publications receiving 1170 citations. Previous affiliations of Andrew D A C Smith include University of New South Wales & University of Bristol.
Papers
More filters
Journal ArticleDOI
Prenatal exposure to maternal smoking and offspring DNA methylation across the lifecourse: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC)
Rebecca C Richmond,Andrew J Simpkin,G. Woodward,Tom R. Gaunt,Oliver Lyttleton,Wendy L. McArdle,Susan M. Ring,Andrew D A C Smith,Nicholas J. Timpson,Kate Tilling,George Davey Smith,Caroline L Relton +11 more
TL;DR: Investigation of associations between prenatal exposure to maternal smoking and offspring DNA methylation at multiple time points in approximately 800 mother–offspring pairs found that the major contribution to altered methylation was attributed to a critical window of in utero exposure.
Journal ArticleDOI
Sensitive Periods for the Effect of Childhood Adversity on DNA Methylation: Results From a Prospective, Longitudinal Study.
Erin C. Dunn,Thomas W. Soare,Thomas W. Soare,Yiwen Zhu,Andrew J Simpkin,Matthew Suderman,Torsten Klengel,Torsten Klengel,Andrew D A C Smith,Kerry J. Ressler,Kerry J. Ressler,Caroline L Relton +11 more
TL;DR: The developmental timing of adversity explains more variability in DNAm than the accumulation or recency of exposure, and very early childhood appears to be a sensitive period when exposure to adversity predicts differential DNAm patterns.
Journal ArticleDOI
Live-Birth Rate Associated With Repeat In Vitro Fertilization Treatment Cycles
TL;DR: The findings support the efficacy of extending the number of IVF cycles beyond 3 or 4 and the cumulative prognosis-adjusted live-birth rate across all cycles in all women and by age and treatment type.
Journal ArticleDOI
What life course theoretical models best explain the relationship between exposure to childhood adversity and psychopathology symptoms: Recency, accumulation, or sensitive periods?
Erin C. Dunn,Thomas W. Soare,Miriam R. Raffeld,Daniel S. Busso,Katherine Crawford,Kathryn A. Davis,Virginia A. Fisher,Natalie Slopen,Andrew D A C Smith,Henning Tiemeier,Ezra Susser +10 more
TL;DR: Child psychopathology symptoms are primarily explained by recency and accumulation models, which underscore the need to measure the characteristics of adversity, which can aid in understanding disease mechanisms and determining how best to reduce the consequences of exposure to adversity.
Journal ArticleDOI
Adversity exposure during sensitive periods predicts accelerated epigenetic aging in children
Sandro Marini,Kathryn A. Davis,Thomas W. Soare,Yiwen Zhu,Matthew Suderman,Andrew J Simpkin,Andrew D A C Smith,Erika J. Wolf,Caroline L Relton,Erin C. Dunn +9 more
TL;DR: Exposure to abuse, financial hardship, or neighborhood disadvantage during sensitive periods in early and middle childhood best explained variability in the deviation of Hannum-based epigenetic age from chronological age, even after considering the role of adversity accumulation and recency.