Prenatal exposure to maternal smoking and offspring DNA methylation across the lifecourse: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC)
Rebecca C Richmond,Andrew J Simpkin,G. Woodward,Tom R. Gaunt,Oliver Lyttleton,Wendy L. McArdle,Susan M. Ring,Andrew D A C Smith,Nicholas J. Timpson,Kate Tilling,George Davey Smith,Caroline L Relton +11 more
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TLDR
Investigation of associations between prenatal exposure to maternal smoking and offspring DNA methylation at multiple time points in approximately 800 mother–offspring pairs found that the major contribution to altered methylation was attributed to a critical window of in utero exposure.Abstract:
Maternal smoking during pregnancy has been found to influence newborn DNA methylation in genes involved in fundamental developmental processes. It is pertinent to understand the degree to which the offspring methylome is sensitive to the intensity and duration of prenatal smoking. An investigation of the persistence of offspring methylation associated with maternal smoking and the relative roles of the intrauterine and postnatal environment is also warranted. In the Avon Longitudinal Study of Parents and Children, we investigated associations between prenatal exposure to maternal smoking and offspring DNA methylation at multiple time points in approximately 800 mother–offspring pairs. In cord blood, methylation at 15 CpG sites in seven gene regions (AHRR, MYO1G, GFI1, CYP1A1, CNTNAP2, KLF13 and ATP9A) was associated with maternal smoking, and a dose-dependent response was observed in relation to smoking duration and intensity. Longitudinal analysis of blood DNA methylation in serial samples at birth, age 7 and 17 years demonstrated that some CpG sites showed reversibility of methylation (GFI1, KLF13 and ATP9A), whereas others showed persistently perturbed patterns (AHRR, MYO1G, CYP1A1 and CNTNAP2). Of those showing persistence, we explored the effect of postnatal smoke exposure and found that the major contribution to altered methylation was attributed to a critical window of in utero exposure. A comparison of paternal and maternal smoking and offspring methylation showed consistently stronger maternal associations, providing further evidence for causal intrauterine mechanisms. These findings emphasize the sensitivity of the methylome to maternal smoking during early development and the long-term impact of such exposure.read more
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Journal ArticleDOI
DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis
Bonnie R. Joubert,Janine F. Felix,Paul Yousefi,Kelly M. Bakulski,Allan C. Just,Carrie V. Breton,Sarah E. Reese,Christina A. Markunas,Christina A. Markunas,Rebecca C Richmond,Cheng-Jian Xu,Leanne K. Küpers,Sam S. Oh,Cathrine Hoyo,Olena Gruzieva,Cilla Söderhäll,Lucas A. Salas,Nour Baïz,Hongmei Zhang,Johanna Lepeule,Carlos Ruiz,Symen Ligthart,Tianyuan Wang,Jack A. Taylor,Liesbeth Duijts,Gemma C Sharp,Soesma A Jankipersadsing,Roy Miodini Nilsen,Ahmad Vaez,Ahmad Vaez,M. Daniele Fallin,Donglei Hu,Augusto A. Litonjua,Bernard F. Fuemmeler,Karen Huen,Juha Kere,Inger Kull,Monica Cheng Munthe-Kaas,Ulrike Gehring,Mariona Bustamante,Marie José Saurel-Coubizolles,Bilal M. Quraishi,Jie Ren,Jörg Tost,Juan R. González,Marjolein J. Peters,Siri E. Håberg,Zongli Xu,Joyce B. J. van Meurs,Tom R. Gaunt,Marjan Kerkhof,Eva Corpeleijn,Andrew P. Feinberg,Celeste Eng,Andrea A. Baccarelli,Sara E. Benjamin Neelon,Asa Bradman,Simon Kebede Merid,Anna Bergström,Zdenko Herceg,Hector Hernandez-Vargas,Bert Brunekreef,Mariona Pinart,Barbara Heude,Susan Ewart,Jin Yao,Nathanaël Lemonnier,Oscar H. Franco,Michael C. Wu,Albert Hofman,Albert Hofman,Wendy L. McArdle,Pieter van der Vlies,Fahimeh Falahi,Matthew W. Gillman,Lisa F. Barcellos,Ashok Kumar,Ashok Kumar,Ashok Kumar,Magnus Wickman,Magnus Wickman,Stefano Guerra,Marie-Aline Charles,John W. Holloway,Charles Auffray,Henning Tiemeier,George Davey Smith,Dirkje S. Postma,Marie-France Hivert,Brenda Eskenazi,Martine Vrijheid,Hasan Arshad,Josep M. Antó,Abbas Dehghan,Wilfried Karmaus,Isabella Annesi-Maesano,Jordi Sunyer,Akram Ghantous,Göran Pershagen,Nina Holland,Susan K. Murphy,Dawn L. DeMeo,Esteban G. Burchard,Christine Ladd-Acosta,Harold Snieder,Wenche Nystad,Gerard H. Koppelman,Caroline L Relton,Vincent W. V. Jaddoe,Allen J. Wilcox,Erik Melén,Erik Melén,Stephanie J. London +112 more
TL;DR: This large scale meta-analysis of methylation data identified numerous loci involved in response to maternal smoking in pregnancy with persistence into later childhood and provide insights into mechanisms underlying effects of this important exposure.
Journal ArticleDOI
Data Resource Profile: Accessible Resource for Integrated Epigenomic Studies (ARIES)
Caroline L Relton,Tom R. Gaunt,Wendy L. McArdle,Karen M Ho,Aparna Duggirala,Hashem A. Shihab,G. Woodward,Oliver Lyttleton,David M. Evans,Wolf Reik,Yu-Lee Paul,Gabriella Ficz,Susan E. Ozanne,Anil Wipat,Keith Flanagan,Allyson L. Lister,Bastiaan T. Heijmans,Susan M. Ring,George Davey Smith +18 more
TL;DR: Data Resource Profile: Accessible Resource for Integrated Epigenomic Studies (ARIES) Caroline L Relton, Tom Gaunt, Wendy McArdle, Karen Ho, Aparna Duggirala, Hashem Shihab, Geoff Woodward, Oliver Lyttleton, David M Evans, Wolf Reik, Yu-Lee Paul, Gabriella Ficz, Susan E Ozanne and Susan M Ring.
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Small-Magnitude Effect Sizes in Epigenetic End Points are Important in Children's Environmental Health Studies: The Children's Environmental Health and Disease Prevention Research Center's Epigenetics Working Group.
Carrie V. Breton,Carmen J. Marsit,Elaine M. Faustman,Kari C. Nadeau,Kari C. Nadeau,Jaclyn M. Goodrich,Dana C. Dolinoy,Julie B. Herbstman,Nina Holland,Janine M. LaSalle,Rebecca J. Schmidt,Paul Yousefi,Frederica P. Perera,Bonnie R. Joubert,Joseph L. Wiemels,Michele M. Taylor,Ivana V. Yang,Rui Chen,Kinjal M. Hew,Deborah M. Hussey Freeland,Rachel L. Miller,Susan K. Murphy +21 more
TL;DR: The state of the science in environmental epigenetics research is considered and the collective observations of many studies being conducted within the Children’s Environmental Health and Disease Prevention Research Centers, as they relate to the Developmental Origins of Health and disease (DOHaD) hypothesis are focused on.
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Epigenetics and allergy: from basic mechanisms to clinical applications
Daniel P. Potaczek,Hani Harb,Hani Harb,Sven Michel,Bilal Alashkar Alhamwe,Harald Renz,Harald Renz,Jörg Tost +7 more
TL;DR: The potential of epigenetic changes for various clinical applications is shown: as diagnostic tools, to assess tolerance following immunotherapy or possibly predict the success of therapy at an early time point and new technological advances such as epigenome editing and DNAzymes will allow targeted alterations of the epigenome in the future and provide novel therapeutic tools.
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Epigenome-wide Association Studies and the Interpretation of Disease -Omics.
TL;DR: Many of the problems with current epigenomic studies are defined and solutions that can be applied are proposed to allow this and other disease -omics studies to achieve their potential for generating valuable insights.
References
More filters
Journal ArticleDOI
Random-effects models for longitudinal data
Nan M. Laird,James H. Ware +1 more
TL;DR: In this article, a unified approach to fitting two-stage random-effects models, based on a combination of empirical Bayes and maximum likelihood estimation of model parameters and using the EM algorithm, is discussed.
Journal ArticleDOI
‘Mendelian randomization’: can genetic epidemiology contribute to understanding environmental determinants of disease?
George Davey Smith,Shah Ebrahim +1 more
TL;DR: Mendelian randomization provides new opportunities to test causality and demonstrates how investment in the human genome project may contribute to understanding and preventing the adverse effects on human health of modifiable exposures.
Journal ArticleDOI
Controlling the false discovery rate in behavior genetics research
TL;DR: The False Discovery Rate (FDR) is the expected proportion of false discoveries among the discoveries, and controlling the FDR goes a long way towards controlling the increased error from multiplicity while losing less in the ability to discover real differences.
Journal Article
Determinants of low birth weight: Methodological assessment and meta-analysis
TL;DR: There is a need for future research on the effect of maternal work, prenatal care, and certain vitamin and mineral deficiencies on intrauterine growth, and theeffect of genital tract infection, prenatal Care, maternal employment, stress and anxiety on prematurity.
Journal ArticleDOI
Cohort Profile: The ‘Children of the 90s’—the index offspring of the Avon Longitudinal Study of Parents and Children
Andy Boyd,Jean Golding,John Macleod,Debbie A Lawlor,Abigail Fraser,John Henderson,Lynn Molloy,Andy R Ness,Susan M. Ring,George Davey Smith +9 more
TL;DR: The Avon Longitudinal Study of Parents and Children (ALSPAC) is a transgenerational prospective observational study investigating influences on health and development across the life course and is currently set up as a supported access resource.
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