Gabriel Liberatore

TL;DR: It is shown that after administration of MPTP to mice, there was a robust gliosis in the substantia nigra pars compacta associated with significant upregulation of inducible nitric oxide synthase (iNOS), which indicates that inhibitors of iNOS may provide protective benefit in the treatment of Parkinson disease.

TL;DR: In this paper, the pro-apoptotic protein Bax is shown to play a critical role in MPTP neurotoxic process and suggests that targeting Bax may provide protective benefit in the treatment of Parkinson's disease.

TL;DR: Findings support the view that MPTP's deleterious cascade of events include mito-chondrial respiration deficit, oxidative stress, and energy failure, and that a similar scenario applies to the pathogenesis of PD.

TL;DR: It is demonstrated that destruction of intrinsic striatal neurons by a local injection of quinolinic acid (QA) dramatically enhances the magnitude of SNpc apoptosis and results in a lower number of adult SNpc dopaminergic neurons.

TL;DR: It is shown that the pro-apoptotic protein Bax is highly expressed in the SNpc and that its ablation attenuates SNpc developmental neuronal apoptosis, and it is suggested that targeting Bax may provide protective benefit in the treatment of Parkinson's disease.