Gaby Palmer

TL;DR: These findings point toward a critical function of IL-36 in the priming of Th1 cell responses in vitro, and in adaptive immunity in a model of mycobacterial infection in vivo.

TL;DR: Immunoprecipitation confirmed that IL-33 specifically binds ST2 and revealed that cellular IL-1 receptor accessory protein (AcP) associates with ST2 in a ligand-dependent manner, identifying AcP as a shared co-receptor within theIL-1 family that is essential for IL-32 signaling and suggesting a novel role for sAcP in modulating the activity of IL- 33.

TL;DR: The data indicate that MAPKs regulate different stages of MC3T3-E1 cell development in response to FCS, with Erk playing an essential role in cell replication, whereas p38 is involved in the regulation of ALP expression during osteoblastic cell differentiation.

TL;DR: IL-1 blockade by anakinra is dramatically effective in systemic-onset juvenile idiopathic arthritis, in adult Still's disease and in several autoinflammatory disorders, most of the latter being caused by mutations of proteins controlling IL-1beta secretion.

TL;DR: IL-1F8 exerts proinflammatory effects in primary human joint cells, and it remains to be determined whether circulating IL-1f8 can contribute to joint inflammation in rheumatoid arthritis.