Gaby Palmer

TL;DR: In vitro results showed that Pi increases type X collagen expression, and together with Ca, induces apoptosis‐associated mineralization, which is similar to that analyzed in vivo, thus suggesting a role for both ions and apoptosis during endochondral ossification.

TL;DR: Clinical studies have so far yielded inconsistent results, suggesting a rather complex role for leptin in immune-mediated inflammatory conditions in humans, and it exerts protective anti-inflammatory effects in models of acute inflammation and during activation of innate immune responses.

TL;DR: Different roles for ERK and p38 MAP kinase pathways in regulating activity of MC3T3-E1 osteoblastic cells are suggested, with the ERK pathway likely involved in the control of cell proliferation whereas the p38MAP kinase pathway regulates ALP activity in response to activation of Gi protein-coupled receptors.

TL;DR: IL-38 may exert its anti-inflammatory effects by decreasing the production of proinflammatory cytokines by macrophages and synovial fibroblasts by leading to the development of novel treatment strategies in arthritis.

TL;DR: It is shown that on repeated toll-like receptor 9 (TLR9) stimulation with unmethylated cytosine guanine dinucleotide containing single-stranded DNA (CpG),IL-18BP-/- mice display severe MAS manifestations, and that IL-18, which acts upstream of IFN-γ, is involved in the severity of MAS.