Gal Ben-Josef

TL;DR: It is demonstrated that diet restriction significantly increases SIRT1 protein levels and induces neural activation in the dorsomedial and lateral hypothalamic nuclei, providing insight into the role of the hypothalamus in the regulation of metabolism and aging in mammals.

TL;DR: Trial information and results reported on ClinicalTrials.gov is fairly complete, although there are concerns about its specificity; optional trial registration information is less complete.

TL;DR: ABT-737 might be particularly well suited for enhancing the activity of immunotoxins that translocate from the ER to the cell cytosol, because of its activity in the ER, and possible mechanisms of resistance.

TL;DR: The results indicate that the role of L BP signaling in inflammatory conditions is complex and heterogeneous, and elevated levels of LBP are not always protective, and Increased LBP production in the setting of cholestatic liver disease appears to be deleterious and may represent a potential therapeutic target for preventing overwhelming inflammatory responses to LPS in this setting.

TL;DR: Combined therapy with the BH3-only mimetic, ABT-737, and immunotoxin–ABT combinations often exhibit greater killing activity than either compound alone and in some instances overcome resistance.