Ganapathy Rajaseger

TL;DR: Sub supertypes are defined, where members show functional overlap with identical repertoire, and a strategy to group HLA-A, B and C alleles into different categories of sub supertypes is described, which is moderately validated using available binding data.

TL;DR: A novel predictive model using information gleaned from 29 human MHCp crystal structures that is superior to many existing methods because of its potential application to any given MHC allele whose sequence is clearly defined.

TL;DR: The prevalently dominant SB interactions at the interface suggest the importance of peptide backbone conformation during MHC-peptide binding and hence emphasizes the need for accurate peptideside backbone prediction in quantitative MHC/sidechain binding calculations.

TL;DR: Regression analysis shows that blood and brain gp120 and gp41 percent sequence polarity range correlate with mean Shannon entropy, which point to the use of protein modifications to enhance HIV-1 ENV vaccines across multiple clades, blood, and brain.

TL;DR: OIA demonstrate limits of detection lesser in range to the gold standard mouse bioassay, to standardize a rapid, sensitive and fieldable optical immunoassay for the detection of BoNTs A, B, E and F in food matrices.