Joanne M. Williamson

TL;DR: The findings suggest that the metabolic effects of metformin in subjects with type 2 diabetes may be mediated by the activation of AMPK alpha2, which is implicated in the stimulation of glucose uptake into skeletal muscle and the inhibition of liver gluconeogenesis.

TL;DR: An antimetabolite, THX, was isolated from fermentation broths of the thienamycin producer, Streptomyces cattleya, when the organism was grown in the presence of a fluorine-containing substrate.

TL;DR: The molecular modeling approach was very effective in identifying novel inhibitors of the enzyme and these compounds were obtained at a higher frequency based on the number of compounds analyzed than those inhibitors discovered via conventional screening, however, conventional screening proved beneficial in identifying compounds with greater structural diversity.

TL;DR: L-365,209 represents a unique class of compounds that provides an entirely new approach for the design of antagonists for these neurohypophyseal hormones.

TL;DR: The solution structure of the 39-residue peptide margatoxin, a scorpion toxin that selectively blocks the voltage-gated potassium-channel Kv1.3, has been determined by NMR spectroscopy.