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Xiaolan Shen
Researcher at Merck & Co.
Publications - 34
Citations - 6611
Xiaolan Shen is an academic researcher from Merck & Co.. The author has contributed to research in topics: Insulin & Adipose tissue. The author has an hindex of 19, co-authored 34 publications receiving 6005 citations.
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Journal ArticleDOI
Role of AMP-activated protein kinase in mechanism of metformin action
Gaochao Zhou,Robert W. Myers,Ying Li,Yuli Chen,Xiaolan Shen,Judy Fenyk-Melody,Margaret Wu,John Ventre,Thomas W. Doebber,Nobuharu Fujii,Nicolas Musi,Michael F. Hirshman,Laurie J. Goodyear,David E. Moller +13 more
TL;DR: It is reported that metformin activates AMPK in hepatocytes; as a result, acetyl-CoA carboxylase (ACC) activity is reduced, fatty acid oxidation is induced, and expression of lipogenic enzymes is suppressed.
Journal ArticleDOI
Targeting a ceramide double bond improves insulin resistance and hepatic steatosis.
Bhagirath Chaurasia,Trevor S. Tippetts,Rafael Mayoral Monibas,Jinqi Liu,Ying Li,Liping Wang,Joseph L. Wilkerson,C. Rufus Sweeney,Renato Felipe Pereira,Doris Hissako Sumida,J. Alan Maschek,James E. Cox,Vincent A. Kaddai,Graeme I. Lancaster,Monowarul Mobin Siddique,Annelise M Poss,Mackenzie J. Pearson,Santhosh Satapati,Heather Zhou,David G. McLaren,Stephen F. Previs,Ying Chen,Ying Qian,Aleksandr Petrov,Margaret Wu,Xiaolan Shen,Jun Yao,Christian N. Nunes,Andrew D. Howard,Liangsu Wang,Mark D. Erion,Jared Rutter,Jared Rutter,William L. Holland,David E. Kelley,Scott A. Summers +35 more
TL;DR: Mechanistic studies revealed ceramide actions that promoted lipid uptake and storage and impaired glucose utilization, none of which could be recapitulated by (dihydro)ceramides that lacked the critical double bond, suggest that inhibition of DES1 may provide a means of treating hepatic steatosis and metabolic disorders.
Journal ArticleDOI
The Role of Dipeptidyl Peptidase IV in the Cleavage of Glucagon Family Peptides IN VIVO METABOLISM OF PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE-(1–38)
Lan Zhu,Constantin Tamvakopoulos,Dan Xie,Jasminka Dragovic,Xiaolan Shen,Judith E. Fenyk-Melody,Keith Schmidt,Ansuman Bagchi,Patrick R. Griffin,Nancy A. Thornberry,Ranabir Sinha Roy +10 more
TL;DR: Results suggest that DP-IV plays a major role in the degradation of circulating PACAP38, a critical mediator of lipid and carbohydrate metabolism, and Oxyntomodulin and the growth hormone fragment were identified as new candidate in vivo substrates.
Journal ArticleDOI
Potentiation of Insulin Signaling in Tissues of Zucker Obese Rats After Acute and Long-Term Treatment With PPARγ Agonists
Guoqiang Jiang,Qing Dallas-Yang,Zhihua Li,Deborah Szalkowski,Franklin Liu,Xiaolan Shen,Margaret Wu,Gaochao Zhou,Thomas W. Doebber,Joel Berger,David E. Moller,Bei B. Zhang +11 more
TL;DR: The results suggest that PPARgamma agonists acutely potentiate insulin signaling in adipose and muscle tissues and such regulation may be physiologically relevant to insulin sensitization in vivo.
Journal ArticleDOI
Activation of insulin signal transduction pathway and anti-diabetic activity of small molecule insulin receptor activators.
Sajjad A. Qureshi,Victor D.-H. Ding,Zhihua Li,Deborah Szalkowski,Dawn E. Biazzo-Ashnault,Dan Xie,Richard Saperstein,Edward J. Brady,Su Er W Huskey,Xiaolan Shen,Kun Liu,Libo Xu,Gino Salituro,James V. Heck,David E. Moller,A. Brian Jones,Bei B. Zhang +16 more
TL;DR: The characterization of an active analog (compound 2) with enhanced IR kinase activation potency and selectivity over related receptors (insulin-like growth factor I receptor, epidermal growth factor receptor, and platelet-derived growth factor receptors) is reported.