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Nicolás Herranz
Researcher at Imperial College London
Publications - 12
Citations - 1718
Nicolás Herranz is an academic researcher from Imperial College London. The author has contributed to research in topics: Senescence & PI3K/AKT/mTOR pathway. The author has an hindex of 10, co-authored 12 publications receiving 1056 citations. Previous affiliations of Nicolás Herranz include Hammersmith Hospital.
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Journal ArticleDOI
Mechanisms and functions of cellular senescence
Nicolás Herranz,Jesús Gil +1 more
TL;DR: The mechanisms regulating different aspects of the senescent phenotype and their functional implications are discussed, essential to improve the identification and characterization of senescent cells in vivo and will help to develop rational strategies to modulate the senescence program for therapeutic benefit.
Journal ArticleDOI
mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype
Nicolás Herranz,Suchira Gallage,Massimiliano Mellone,Torsten Wuestefeld,Sabrina Klotz,Christopher J. Hanley,Selina Raguz,Juan Carlos Acosta,Andrew J. Innes,Ana Banito,Athena Georgilis,Alex Montoya,Katharina Wolter,Gopuraja Dharmalingam,Peter Faull,Thomas L. Carroll,Juan Pedro Martinez-Barbera,Pedro R. Cutillas,Pedro R. Cutillas,Florian Reisinger,Mathias Heikenwalder,Mathias Heikenwalder,Richard A. Miller,Dominic J. Withers,Lars Zender,Gareth J. Thomas,Jesús Gil +26 more
TL;DR: A mechanism by which mTOR controls the SASP is reported by differentially regulating the translation of the MK2 (also known as MAPKAPK2) kinase through 4EBP1.
Journal ArticleDOI
Cardiac glycosides are broad-spectrum senolytics
Ana Guerrero,Nicolás Herranz,Bin Sun,Wagner,Suchira Gallage,Suchira Gallage,Romain Guiho,Katharina Wolter,Joaquim Pombo,Elaine E. Irvine,Andrew J. Innes,Jodie Birch,Justyna A. Glegola,Saba Manshaei,Danijela Heide,Gopuraja Dharmalingam,Jule Harbig,Antoni Olona,Jacques Behmoaras,Daniel Dauch,Anthony G. Uren,Lars Zender,Lars Zender,Santiago Vernia,Juan Pedro Martinez-Barbera,Mathias Heikenwalder,Dominic J. Withers,Jesús Gil +27 more
TL;DR: In addition to having direct anti-cancer effects, the cardiac glycoside ouabain is shown to kill a broad range of senescent cells, thus suggesting that cardiac glyCosides represent a novel class of senolytics.
Journal ArticleDOI
PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells.
Athena Georgilis,Sabrina Klotz,Christopher J. Hanley,Nicolás Herranz,Benedikt Weirich,Beatriz Morancho,Ana Carolina Leote,Luana D’Artista,Suchira Gallage,Marco Seehawer,Thomas L. Carroll,Gopuraja Dharmalingam,Keng Boon Wee,Marco Mellone,Joaquim Pombo,Danijela Heide,Ernesto Guccione,Joaquín Arribas,Nuno L. Barbosa-Morais,Mathias Heikenwalder,Gareth J. Thomas,Lars Zender,Jesús Gil +22 more
TL;DR: An RNAi screen for SASP regulators identified 50 druggable targets whose knockdown suppresses the inflammatory secretome and differentially affects other SASP components and identifies SASP inhibition as a powerful and safe therapy against inflammation-driven cancer.
Journal ArticleDOI
Regulation of Heterochromatin Transcription by Snail1/LOXL2 during Epithelial-to-Mesenchymal Transition
Alba Millanes-Romero,Nicolás Herranz,Valentina Perrera,Ane Iturbide,Jordina Loubat-Casanovas,Jesús Gil,Thomas Jenuwein,Antonio García de Herreros,Sandra Peiró +8 more
TL;DR: It is proposed that Snail1 regulates heterochromatin transcription through LOXL2, thus creating the favorable transcriptional state necessary for completing EMT, which compromised the migratory and invasive behavior of mesenchymal cells.