G
Garrett C. Heffner
Researcher at Howard Hughes Medical Institute
Publications - 7
Citations - 1312
Garrett C. Heffner is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Induced pluripotent stem cell & Embryonic stem cell. The author has an hindex of 7, co-authored 7 publications receiving 1242 citations. Previous affiliations of Garrett C. Heffner include Harvard University.
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Journal ArticleDOI
Generation of induced pluripotent stem cells from human blood
Yuin-Han Loh,Yuin-Han Loh,Suneet Agarwal,Suneet Agarwal,In-Hyun Park,In-Hyun Park,Achia Urbach,Achia Urbach,Hongguang Huo,Hongguang Huo,Garrett C. Heffner,Garrett C. Heffner,Kitai Kim,Kitai Kim,Justine D. Miller,Justine D. Miller,Kitwa Ng,Kitwa Ng,George Q. Daley +18 more
TL;DR: The ability to reprogram cells from human blood will allow the generation of patient-specific stem cells for diseases in which the disease-causing somatic mutations are restricted to cells of the hematopoietic lineage.
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Reprogramming of T Cells from Human Peripheral Blood
Yuin-Han Loh,Odelya Hartung,Hu Li,Hu Li,Chunguang Guo,Chunguang Guo,Chunguang Guo,Julie M. Sahalie,Philip D. Manos,Achia Urbach,Garrett C. Heffner,Marica Grskovic,Francois Vigneault,M. William Lensch,M. William Lensch,In-Hyun Park,Suneet Agarwal,George M. Church,James J. Collins,James J. Collins,James J. Collins,Stefan Irion,George Q. Daley +22 more
TL;DR: A manuscript has appeared online demonstrating isolation of iPSCs from peripheral blood, including a single line that showed evidence for both T CR-β and TCR-γ rearrangement by PCR.
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An endothelin receptor B antagonist inhibits growth and induces cell death in human melanoma cells in vitro and in vivo.
TL;DR: It is found that administration of BQ788 significantly slows human melanoma tumor growth in nude mice, including a complete growth arrest in half of the mice treated systemically, suggesting that ETRB inhibitors may be beneficial for the treatment of melanoma.
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Epoxyeicosatrienoic Acids Enhance Embryonic Haematopoiesis and Adult Marrow Engraftment
Pulin Li,Jamie L. Lahvic,Vera Binder,Emily K. Pugach,Elizabeth B. Riley,Owen J. Tamplin,Dipak Panigrahy,Teresa V. Bowman,Francesca G. Barrett,Garrett C. Heffner,Shannon McKinney-Freeman,Thorsten M. Schlaeger,George Q. Daley,Darryl C. Zeldin,Leonard I. Zon +14 more
TL;DR: This study establishes a new method to explore the molecular mechanisms of HSPC engraftment, and discovers a previously unrecognized, evolutionarily conserved pathway regulating multiple haematopoietic generation and regeneration processes.
Journal ArticleDOI
Signaling axis involving Hedgehog, Notch, and Scl promotes the embryonic endothelial-to-hematopoietic transition
Peter Geon Kim,Colleen E. Albacker,Yi Fen Lu,Il Ho Jang,Yoowon Lim,Garrett C. Heffner,Natasha Arora,Teresa V. Bowman,Michelle I. Lin,M. William Lensch,Alejandro De Los Angeles,Leonard I. Zon,Sabine Loewer,George Q. Daley +13 more
TL;DR: The results reveal that Scl overexpression is sufficient to rescue the developmental defects caused by blocking the Hh and Notch pathways, and inform the understanding of the embryonic endothelial-to-hematopoietic transition.