S
Sabine Loewer
Researcher at Boston Children's Hospital
Publications - 11
Citations - 1703
Sabine Loewer is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Stem cell & Embryonic stem cell. The author has an hindex of 8, co-authored 11 publications receiving 1565 citations. Previous affiliations of Sabine Loewer include Harvard University & Brigham and Women's Hospital.
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Journal ArticleDOI
Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration.
Wolfram Goessling,Trista E. North,Trista E. North,Sabine Loewer,Sabine Loewer,Allegra M. Lord,Allegra M. Lord,Sang Lee,Sang Lee,Cristi L. Stoick-Cooper,Gilbert Weidinger,Mark Puder,Mark Puder,George Q. Daley,George Q. Daley,Randall T. Moon,Leonard I. Zon,Leonard I. Zon +17 more
TL;DR: It is shown that wnt reporter activity in zebrafish HSCs is responsive to PGE2 modulation, demonstrating a direct interaction in vivo and suggesting the P GE2/Wnt interaction is a master regulator of vertebrate regeneration and recovery.
Journal ArticleDOI
Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients
Suneet Agarwal,Suneet Agarwal,Yuin-Han Loh,Yuin-Han Loh,Erin M. McLoughlin,Erin M. McLoughlin,Junjiu Huang,Junjiu Huang,In-Hyun Park,In-Hyun Park,Justine D. Miller,Justine D. Miller,Hongguang Huo,Hongguang Huo,Maja Okuka,Rosana Maria dos Reis,Sabine Loewer,Sabine Loewer,Huck-Hui Ng,David L. Keefe,Frederick D. Goldman,Aloysius J. Klingelhutz,Lin Liu,Lin Liu,George Q. Daley,George Q. Daley,George Q. Daley +26 more
TL;DR: It is demonstrated that reprogramming restores telomere elongation in DC cells despite genetic lesions affecting telomerase, and it is shown that strategies to increase TERC expression may be therapeutically beneficial in DC patients.
Journal ArticleDOI
Midbody accumulation through evasion of autophagy contributes to cellular reprogramming and tumorigenicity
Tse-Chun Kuo,Chun-Ting Chen,Desiree M. Baron,Tamer T. Onder,Sabine Loewer,Sandra Almeida,Cara M. Weismann,Ping Xu,JeanMarie Houghton,Fen-Biao Gao,George Q. Daley,Stephen J. Doxsey +11 more
TL;DR: It is shown that MBds are inherited asymmetrically by the daughter cell with the older centrosome, and enriched MBd enrichment enhances reprogramming to induced pluripotent stem cells and increases the in vitro tumorigenicity of cancer cells.
Journal ArticleDOI
The Transcriptional Landscape of Hematopoietic Stem Cell Ontogeny
Shannon McKinney-Freeman,Patrick Cahan,Hu Li,Hu Li,Scott A. Lacadie,Hsuan Ting Huang,Matthew Curran,Sabine Loewer,Olaia Naveiras,Katie L. Kathrein,Martina Konantz,Martina Konantz,Erin M. Langdon,Claudia Lengerke,Leonard I. Zon,James J. Collins,James J. Collins,James J. Collins,George Q. Daley +18 more
TL;DR: The transcriptomes of developing HSCs purified from >2,500 murine embryos and adult mice were acquired and it was found that embryonic hematopoietic elements clustered into three distinct transcriptional states characteristic of the definitive yolk sac, H SCs undergoing specification, and definitive HSCS.
Journal ArticleDOI
Surface antigen phenotypes of hematopoietic stem cells from embryos and murine embryonic stem cells.
Shannon McKinney-Freeman,Shannon McKinney-Freeman,Olaia Naveiras,Olaia Naveiras,Frank Yates,Sabine Loewer,Sabine Loewer,Marsha Philitas,Marsha Philitas,Marsha Philitas,Matthew Curran,Matthew Curran,Peter J. Park,George Q. Daley +13 more
TL;DR: The prospective fractionation of ESC-HSCs will facilitate studies of HSC maturation essential for normal functional engraftment in irradiated adults, and signify a developmentally immature population of cells with features of both primitive and mature HSC.