Garth J. S. Cooper

TL;DR: The homeostasis of Cu and eight other nutritionally essential elements in diabetes under fully residential conditions in male subjects with type 2 diabetes and age-matched control subjects is characterized and cardiovascular complications in diabetes might be better controlled by therapeutic strategies that focus on lowering plasma glucose and loosely bound systemic Cu(II).

TL;DR: Obese animals showed significantly increased glucose incorporation into lipid in all of these tissues, indicating an increase in lipogenesis, and an integrated characterisation of in vivo insulin resistance in obese ZDF rats is presented.

TL;DR: It is concluded that adrenomedullin regulates osteoblast function and that it increases bone mass in vivo and the potential of this family of peptides in the therapy of osteoporosis should be further evaluated.

TL;DR: The threshold for biological activity of adrenomedullin in man is lower, for arterial pressure than for renal or hormonal responses, and is evident at plasma concentrations seen in disorders of the circulation, suggesting it may be an important hormone under pathophysiological circumstances.

TL;DR: Cell proliferation was consistently less with the TFA salts of these peptides, resulting in failure to detect a proliferative effect or wrongly attributing an antiproliferative effect, and is likely to be relevant to all studies of purified peptides in concentrations above 10-9 M in whatever cell or tissue type.