G
Garth J. S. Cooper
Researcher at University of Auckland
Publications - 309
Citations - 17579
Garth J. S. Cooper is an academic researcher from University of Auckland. The author has contributed to research in topics: Amylin & Insulin. The author has an hindex of 63, co-authored 299 publications receiving 16490 citations. Previous affiliations of Garth J. S. Cooper include Manchester Academic Health Science Centre & University of Manchester.
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A possible mechanism of toxicity by the antidepressant amoxapine based on its effects in three in vitro models
TL;DR: Investigation of in vitro systems found that membrane-stabilizing activity alone is not adequate to explain the action of amoxapine on isolated cells, on the perfused arrested heart, or the clinical pattern of overdose, and disruption of energy conservation in cells is likely to be involved also.
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Synthesis, crystal structure, and protonation behaviour in solution of the recently-discovered drug metabolite, N1,N10-diacetyltriethylenetetramine
TL;DR: In this article, the synthesis of DAT dihydrochloride (DAT·2 HCl) was reported, and its crystal structure was determined by X-ray single-crystal (XRD) and powder diffraction (XRPD).
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Identification and characterization of a bovine myosin light chain-1 fast polymorphism
TL;DR: A previously uncharacterized polymorphism of a high expression myofibrillar protein, myosin light chain 1 fast (MLC‐1f), was observed and was shown to be the product of two alleles that are codominant.
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Contrasting Sodium and Potassium Perturbations in the Hippocampus Indicate Potential Na+/K+-ATPase Dysfunction in Vascular Dementia
Sasha A. Philbert,Jingshu Xu,Melissa Scholefield,Stephanie J. Church,Richard D. Unwin,Garth J. S. Cooper +5 more
TL;DR: No distinguishable hippocampal differences in metal-evoked patterns between these dementia-causing diseases are revealed in this study, which highlights the potential diagnostic importance of cerebral sodium measurement in VaD patients.
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Pancreas Fat, an Early Marker of Metabolic Risk? A Magnetic Resonance Study of Chinese and Caucasian Women: TOFI_Asia Study
Ivana R. Sequeira,Wilson Yip,Louise Weiwei Lu,Yannan Jiang,Rinki Murphy,Lindsay D. Plank,Garth J. S. Cooper,Carl Peters,Jun Lu,Kieren G. Hollingsworth,Sally D. Poppitt +10 more
TL;DR: Pancreas fat accumulation may be an early adverse event, in TOFI individuals, with peptides highlighting pancreatic dysfunction as drivers of T2D susceptibility.