Garth J. S. Cooper

TL;DR: Proteomic changes in diabetic rat heart mitochondria following 120 days of streptozotocin‐diabetes are reported using the recently developed iTRAQ™ labeling method, which permits quantification of proteins directly from complex mixtures, bypassing the limitations associated with gel‐based methods such as 2‐DE.

TL;DR: Somatostatin and calcitonin gene-related peptide, fragment 28-37 were shown to inhibit glucose-stimulated insulin release as assessed by the size of individual plaques and the number of recruited B cells, and hence to reduce the total area of plaques formed, suggesting that these peptides which can be immunolocalised in islet cells may have a role in the regulation of insulin secretion.

TL;DR: C cerebral pantothenate deficiency is a newly-identified metabolic defect in human HD that could potentially impair neuronal CoA biosynthesis; stimulate polyol-pathway activity; impair glycolysis and tricarboxylic acid cycle activity; and modify brain-urea metabolism.

TL;DR: The results suggest that, whereas alterations in cytosolic Ca(2+) homoeostasis do have a significant role in certain forms of beta-cell death, they do not contribute to the pathway of apoptosis evoked by hA in islet beta-cells.

TL;DR: Proteins present in purified granules from the INS-1E beta-cell model identified by LC-MS/MS may increase understanding of granule secretion and the processes leading to protein aggregation and beta- cell death in type-2 diabetes.