Garth J. S. Cooper

TL;DR: Brain urea metabolism is a target for generating novel monitoring/imaging strategies and/or therapeutic interventions aimed at ameliorating the impact of HD in patients, and hypothesize that defective brain Urea metabolism could play a substantive role in the pathogenesis of neurodegeneration, perhaps via defects in osmoregulation or nitrogen metabolism.

TL;DR: Metabolomic studies have shown that the STZ-induced rat model of diabetes is an appropriate model system to undertake research into diabetes and potential therapies as several metabolic changes observed in humans and other animal models were also observed in this study.

TL;DR: It is demonstrated that, in the circulation, adiponectin forms protein complexes with other serum proteins that might serve as the physiological‐binding partners of adiponECTin and regulate its bioavailability and biological activities.

TL;DR: This is the first report to show that treating hA/hIAPP transgenic mice with a modifier of hA-IAPP misfolding can ameliorate their diabetic phenotype, and may have potential for treating or preventing type 2 diabetes.

TL;DR: These studies provide the first evidence that there is a mechanism within the pancreas whereby independent secretion of amylin and insulin can occur and the molar ratio ofAmylin to insulin secreted from both normal and diabetic pancreases can vary over a wide range.