G
Garth Powis
Researcher at Discovery Institute
Publications - 195
Citations - 12010
Garth Powis is an academic researcher from Discovery Institute. The author has contributed to research in topics: Thioredoxin & Thioredoxin reductase. The author has an hindex of 57, co-authored 194 publications receiving 11475 citations. Previous affiliations of Garth Powis include University of Texas Health Science Center at Houston & Mayo Clinic.
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Journal ArticleDOI
Phase II Pilot Study of Vemurafenib in Patients With Metastatic BRAF-Mutated Colorectal Cancer.
Scott Kopetz,Jayesh Desai,Emily Chan,J. R. Hecht,Peter J. O'Dwyer,Dipen M. Maru,Van K. Morris,Filip Janku,Arvind Dasari,Woonbook Chung,Jean Pierre J. Issa,Peter Gibbs,Peter Gibbs,Brian P. James,Garth Powis,K. B. Nolop,Suman Bhattacharya,Leonard B. Saltz +17 more
TL;DR: Single-agent vemurafenib did not show meaningful clinical activity in patients with BRAF V600E mutant CRC, and combination strategies are now under development and may be informed by the presence of intratumor heterogeneity of KRAS and NRAS mutations.
Journal ArticleDOI
Properties and Biological Activities of Thioredoxins
Garth Powis,William R. Montfort +1 more
TL;DR: The mammalian thioredoxins are a family of small redox proteins that undergo NADPH-dependent reduction by thiOREDoxin reductase and in turn reduce oxidized cysteine groups on proteins.
Journal ArticleDOI
Free radical formation by antitumor quinones
TL;DR: The evidence for a relationship between radical formation and the biological activity of the antitumor quinones is evaluated and it is suggested that cardiotoxicity and skin toxicity may also be related to oxygen radical formation.
Journal Article
The Redox Protein Thioredoxin-1 (Trx-1) Increases Hypoxia-inducible Factor 1α Protein Expression: Trx-1 Overexpression Results in Increased Vascular Endothelial Growth Factor Production and Enhanced Tumor Angiogenesis
TL;DR: The results suggest that Trx-1 increases HIF-1alpha protein levels in cancer cells and increases VEGF production and tumor angiogenesis.
Journal ArticleDOI
Properties and biological activities of thioredoxins.
Garth Powis,William R. Montfort +1 more
TL;DR: The mammalian thioredoxins are a family of small (approximately 12 kDa) redox proteins that undergo NADPH-dependent reduction by Thioredoxin reductase and in turn reduce oxidized cysteine groups on proteins as mentioned in this paper.