G
Gary Bellinger
Researcher at Yale University
Publications - 5
Citations - 644
Gary Bellinger is an academic researcher from Yale University. The author has contributed to research in topics: Cancer & DNA repair. The author has an hindex of 5, co-authored 5 publications receiving 484 citations. Previous affiliations of Gary Bellinger include Beth Israel Deaconess Medical Center.
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Journal ArticleDOI
AMPK-Dependent Degradation of TXNIP upon Energy Stress Leads to Enhanced Glucose Uptake via GLUT1
Ning Wu,Bin Zheng,Adam J. Shaywitz,Yossi Dagon,Christine Tower,Gary Bellinger,Che Hung Shen,Jennifer Wen,John M. Asara,Timothy E. McGraw,Barbara B. Kahn,Lewis C. Cantley,Lewis C. Cantley +12 more
TL;DR: The glucose influx through GLUT1 restores ATP-to-ADP ratios in the short run and ultimately induces TXNIP protein production to suppress glucose uptake once energy homeostasis is reestablished.
Journal ArticleDOI
Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion.
Ashish Juvekar,Hai Hu,Sina Yadegarynia,Costas A. Lyssiotis,Soumya Ullas,Evan C. Lien,Gary Bellinger,Jaekyoung Son,Rosanna C. Hok,Pankaj Seth,Michele B. Daly,Baek Kim,Ralph Scully,John M. Asara,Lewis C. Cantley,Gerburg M. Wulf +15 more
TL;DR: It is shown that enhanced DNA damage induced by PI3K inhibitors in this mutational background is a consequence of impaired production of nucleotides needed for DNA synthesis and DNA repair.
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Demethylation Therapy as a Targeted Treatment for Human Papillomavirus–Associated Head and Neck Cancer
Asel Biktasova,Michael Hajek,Andrew Sewell,Cyril S. Gary,Gary Bellinger,Hari Anant Deshpande,Aarti K. Bhatia,Barbara Burtness,Barbara Burtness,Benjamin L. Judson,Benjamin L. Judson,Saral Mehra,Wendell G. Yarbrough,Wendell G. Yarbrough,Natalia Issaeva,Natalia Issaeva +15 more
TL;DR: Clinical trial and experimental data show that 5-aza induced growth inhibition and cell death in HPV+ HNSCC, and may provide effective therapy for HPV-associated H NSCC as an alternative or complement to standard cytotoxic therapy.
Journal ArticleDOI
Selective antitumor activity of roscovitine in head and neck cancer.
Cyril S. Gary,Michael Hajek,Asel Biktasova,Gary Bellinger,Wendell G. Yarbrough,Natalia Issaeva +5 more
TL;DR: It is shown that roscovitine, a cyclin-dependent kinase (CDK) inhibitor, causes significant DNA damage followed by p53-dependent cell death in human papilloma virus (HPV)-positive, but not in HPV-negative, head and neck cancer cells.
Journal ArticleDOI
Loss of LZAP inactivates p53 and regulates sensitivity of cells to DNA damage in a p53-dependent manner.
J. Jacob Wamsley,Cyril S. Gary,Asel Biktasova,Michael Hajek,Gary Bellinger,Renu K. Virk,Natalia Issaeva,Wendell G. Yarbrough +7 more
TL;DR: It is shown that leucine zipper-containing ARF-binding protein (LZAP) binds and stabilizes p53, and establishes LZAP as a p53 regulator and p53-dependent determinative of cell fate in response to DNA damaging treatment.