E
Evan C. Lien
Researcher at Massachusetts Institute of Technology
Publications - 31
Citations - 2094
Evan C. Lien is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Protein kinase B & Cancer. The author has an hindex of 16, co-authored 27 publications receiving 1388 citations. Previous affiliations of Evan C. Lien include Harvard University & University of North Carolina at Chapel Hill.
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Journal ArticleDOI
PI3K signaling in cancer: beyond AKT.
TL;DR: Three PI3K-dependent, but AKT-independent, signaling branches that have recently been shown to have important roles in promoting phenotypes associated with malignancy are highlighted.
Journal ArticleDOI
Phosphoinositide 3-Kinase Regulates Glycolysis through Mobilization of Aldolase from the Actin Cytoskeleton
Hai Hu,Ashish Juvekar,Costas A. Lyssiotis,Evan C. Lien,John G. Albeck,Doogie Oh,Gopal Varma,Yin P Hung,Soumya Ullas,Josh Lauring,Pankaj Seth,Mark R. Lundquist,Dean R. Tolan,Aaron K. Grant,Daniel J. Needleman,John M. Asara,Lewis C. Cantley,Gerburg M. Wulf +17 more
TL;DR: A master regulatory function of PI3K is pointed toward that integrates an epithelial cell's metabolism and its form, shape, and function, coordinating glycolysis with the energy-intensive dynamics of actin remodeling.
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Glutathione biosynthesis is a metabolic vulnerability in PI(3)K/Akt-driven breast cancer
Evan C. Lien,Costas A. Lyssiotis,Ashish Juvekar,Hai Hu,John M. Asara,Lewis C. Cantley,Alex Toker +6 more
TL;DR: In mammary epithelial cells, oncogenic PI(3)K/Akt stimulates glutathione (GSH) biosynthesis by stabilizing and activating NRF2 to upregulate the GSH biosynthetic genes, providing insight into G SH biosynthesis as a metabolic vulnerability associated with PI( 3)K pathway mutant breast cancers.
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Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth
Andrew G. Cox,Katie L. Hwang,Katie L. Hwang,Kristin K. Brown,Kimberley J. Evason,Sebastian Beltz,Allison Tsomides,Keelin O’Connor,Giorgio G. Galli,Dean Yimlamai,Sagar Chhangawala,Min Yuan,Evan C. Lien,Julia Wucherpfennig,Sahar Nissim,Akihiro Minami,David E. Cohen,Fernando D. Camargo,Fernando D. Camargo,John M. Asara,Yariv Houvras,Didier Y.R. Stainier,Wolfram Goessling +22 more
TL;DR: It is demonstrated that transgenic zebrafish expressing an activated form of the Hippo pathway effector Yap1 develop enlarged livers and are prone to liver tumour formation by reprogramming nitrogen metabolism to stimulate nucleotide biosynthesis.
Journal ArticleDOI
MSC-regulated microRNAs converge on the transcription factor FOXP2 and promote breast cancer metastasis.
Benjamin G. Cuiffo,Antoine Campagne,Antoine Campagne,George W. Bell,Antonio Lembo,Francesca Orso,Evan C. Lien,Manoj Bhasin,Monica Raimo,Summer E. Hanson,Andriy Marusyk,Dorraya El-Ashry,Peiman Hematti,Kornelia Polyak,Fatima Mechta-Grigoriou,Odette Mariani,Stefano Volinia,Anne Vincent-Salomon,Daniela Taverna,Antoine E. Karnoub,Antoine E. Karnoub +20 more
TL;DR: It is shown that MSCs cause aberrant expression of microRNAs, which, led by microRNA-199a, provide BCCs with enhanced cancer stem cell (CSC) properties and that FOXP2 knockdown in BCCs was sufficient in promoting CSC propagation, tumor initiation, and metastasis.