Jaekyoung Son

TL;DR: In vivo mechanistic insights are provided into how oncogenic Kras promotes metabolic reprogramming in native tumors and illuminates potential metabolic targets that can be exploited for therapeutic benefit in PDAC.

TL;DR: The identification of a non-canonical pathway of glutamine use in human pancreatic ductal adenocarcinoma (PDAC) cells is reported and it is established that the reprogramming of glutamines metabolism is mediated by oncogenic KRAS, the signature genetic alteration in PDAC, through the transcriptional upregulation and repression of key metabolic enzymes in this pathway.

TL;DR: NADPH is used for both macromolecular biosynthesis and the maintenance of a reduced intracellular environment, which makes the genera-tion of NADPH rate limiting for cellular proliferation.

TL;DR: It is demonstrated that ARS2 (arsenite-resistance protein 2), a zinc finger protein that is essential for early mammalian development, plays critical roles in GSC maintenance and M2-like TAM polarization, and a role for the ARs2/MAGL signalling in regulating self-renewal and tumorigenicity of GSCs and M1- like TAM polarization is demonstrated.

TL;DR: It is shown that enhanced DNA damage induced by PI3K inhibitors in this mutational background is a consequence of impaired production of nucleotides needed for DNA synthesis and DNA repair.