H
Hai Hu
Researcher at Sun Yat-sen University
Publications - 62
Citations - 2901
Hai Hu is an academic researcher from Sun Yat-sen University. The author has contributed to research in topics: Cancer & Breast cancer. The author has an hindex of 24, co-authored 53 publications receiving 2298 citations. Previous affiliations of Hai Hu include Peking Union Medical College & Harvard University.
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Journal ArticleDOI
Combining a PI3K Inhibitor with a PARP Inhibitor Provides an Effective Therapy for BRCA1-Related Breast Cancer
Ashish Juvekar,Laura N. Burga,Hai Hu,Elaine P. Lunsford,Yasir H. Ibrahim,Judith Balmaña,Anbazhagan Rajendran,Antonella Papa,Katherine Spencer,Costas A. Lyssiotis,Caterina Nardella,Pier Paolo Pandolfi,José Baselga,Ralph Scully,John M. Asara,Lewis C. Cantley,Gerburg M. Wulf +16 more
TL;DR: The combination of a PI3K inhibitor with a PARP inhibitor provides in vivo synergy for treatment of an endogenous mouse model for BRCA1-related breast cancers, making this a candidate combination to be tested in human clinical trials.
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Phosphoinositide 3-Kinase Regulates Glycolysis through Mobilization of Aldolase from the Actin Cytoskeleton
Hai Hu,Ashish Juvekar,Costas A. Lyssiotis,Evan C. Lien,John G. Albeck,Doogie Oh,Gopal Varma,Yin P Hung,Soumya Ullas,Josh Lauring,Pankaj Seth,Mark R. Lundquist,Dean R. Tolan,Aaron K. Grant,Daniel J. Needleman,John M. Asara,Lewis C. Cantley,Gerburg M. Wulf +17 more
TL;DR: A master regulatory function of PI3K is pointed toward that integrates an epithelial cell's metabolism and its form, shape, and function, coordinating glycolysis with the energy-intensive dynamics of actin remodeling.
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Active Pin1 is a key target of all- trans retinoic acid in acute promyelocytic leukemia and breast cancer
Shuo Wei,Shingo Kozono,Lev Kats,Morris Nechama,Wenzong Li,Jlenia Guarnerio,Man-Li Luo,Mi Hyeon You,Yandan Yao,Asami Kondo,Hai Hu,Gunes Bozkurt,Nathan J. Moerke,Shugeng Cao,Shugeng Cao,Markus Reschke,Chun Hau Chen,Eduardo Magalhães Rego,Francesco Lo-Coco,Lewis C. Cantley,Tae Ho Lee,Hao Wu,Yan Zhang,Pier Paolo Pandolfi,Xiao Zhen Zhou,Kun Ping Lu +25 more
TL;DR: ATRA-induced Pin1 ablation simultaneously blocks multiple Pin1-regulated cancer-driving pathways, an attractive property for treating aggressive and drug-resistant tumors.
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Glutathione biosynthesis is a metabolic vulnerability in PI(3)K/Akt-driven breast cancer
Evan C. Lien,Costas A. Lyssiotis,Ashish Juvekar,Hai Hu,John M. Asara,Lewis C. Cantley,Alex Toker +6 more
TL;DR: In mammary epithelial cells, oncogenic PI(3)K/Akt stimulates glutathione (GSH) biosynthesis by stabilizing and activating NRF2 to upregulate the GSH biosynthetic genes, providing insight into G SH biosynthesis as a metabolic vulnerability associated with PI( 3)K pathway mutant breast cancers.
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Secreted LOXL2 is a novel therapeutic target that promotes gastric cancer metastasis via the Src/FAK pathway
Liang Peng,Yu Liang Ran,Hai Hu,Long Yu,Qian Liu,Zhuan Zhou,Yue Min Sun,Li Chao Sun,Jian Pan,Li Xin Sun,Ping Zhao,Zhi Hua Yang +11 more
TL;DR: Overall, the data revealed that LOXL2 overexpression, a frequent event in gastric carcinoma progression, contributes to tumor cell invasion and metastasis, andLOXL2 may be a therapeutic target for preventing and treating metastases.