G
Gary D. Wu
Researcher at University of Pennsylvania
Publications - 178
Citations - 28135
Gary D. Wu is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Gut flora & Microbiome. The author has an hindex of 55, co-authored 153 publications receiving 23124 citations. Previous affiliations of Gary D. Wu include Children's Hospital of Philadelphia & University of Michigan.
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Journal ArticleDOI
Linking Long-Term Dietary Patterns with Gut Microbial Enterotypes
Gary D. Wu,Jun Chen,Christian Hoffmann,Christian Hoffmann,Kyle Bittinger,Ying-Yu Chen,Sue A. Keilbaugh,Meenakshi Bewtra,Dan Knights,William A. Walters,Rob Knight,Rohini Sinha,Erin Gilroy,Kernika Gupta,Robert N. Baldassano,Lisa Nessel,Hongzhe Li,Frederic D. Bushman,James D. Lewis +18 more
TL;DR: Alternative enterotype states are associated with long-term diet, particularly protein and animal fat (Bacteroides) versus carbohydrates (Prevotella) and other enterotypes distinguished primarily by levels of Bacteroide and Prevotella.
Journal ArticleDOI
Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis
Robert A. Koeth,Zeneng Wang,Bruce S. Levison,Jennifer A. Buffa,Elin Org,Brendan Sheehy,Earl B. Britt,Xiaoming Fu,Yuping Wu,Lin Li,Jonathan D. Smith,Joseph A. DiDonato,Jun Chen,Hongzhe Li,Gary D. Wu,James D. Lewis,Manya Warrier,J. Mark Brown,Ronald M. Krauss,W.H. Wilson Tang,Frederic D. Bushman,Aldons J. Lusis,Stanley L. Hazen +22 more
TL;DR: It is demonstrated that metabolism by intestinal microbiota of dietary l-carnitine, a trimethylamine abundant in red meat, also produces TMAO and accelerates atherosclerosis in mice, and intestinal microbiota may contribute to the well-established link between high levels of red meat consumption and CVD risk.
Journal ArticleDOI
High-fat diet determines the composition of the murine gut microbiome independently of obesity.
Marie A. Hildebrandt,Christian Hoffmann,Scott Sherrill-Mix,Sue A. Keilbaugh,Micah Hamady,Ying-Yu Chen,Rob Knight,Rexford S. Ahima,Frederic D. Bushman,Gary D. Wu +9 more
TL;DR: In this paper, the authors used the phenotype of RELMβ knockout mice to assess the influence of host phenotype, genotype, immune function, and diet on the composition of the human gut microbiome.
Journal ArticleDOI
KILLER/DR5 is a DNA damage–inducible p53–regulated death receptor gene
G. S. Wu,Timothy F. Burns,E. R. McDonald,W. Jiang,R. Meng,Ian D. Krantz,Gary D. Kao,D. D. Gan,Jun Ying Zhou,Ruth J. Muschel,Stanley R. Hamilton,Nancy B. Spinner,Sanford D. Markowitz,Gary D. Wu,Wafik S. El-Deiry +14 more
BASIC—ALIMENTARY TRACT High-Fat Diet Determines the Composition of the Murine Gut Microbiome Independently of Obesity
Marie A. Hildebrandt,Christian Hoffmann,Sue A. Keilbaugh,Micah Hamady,Rob Knight,Rexford S. Ahima,Frederic D. Bushman,Gary D. Wu +7 more
TL;DR: The results demonstrate the importance of diet as a determinant of gut microbiome composition and suggest the need to control for dietary variation when evaluating the composition of the human gut microbiome.