G
Gary M. Brittenham
Researcher at Columbia University
Publications - 262
Citations - 17412
Gary M. Brittenham is an academic researcher from Columbia University. The author has contributed to research in topics: Anemia & Iron deficiency. The author has an hindex of 62, co-authored 252 publications receiving 16156 citations. Previous affiliations of Gary M. Brittenham include Columbia University Medical Center & MetroHealth.
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Journal ArticleDOI
Iron-chelating therapy and the treatment of thalassemia
TL;DR: The toxicity of this agent mandates a careful evaluation of the balance between risk and benefit of deferiprone in patients with thalassemia, in most of whom long-term deferoxamine is safe and efficacious therapy.
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Biomarkers of Nutrition for Development (BOND)-Iron Review.
Sean Lynch,Christine M. Pfeiffer,Michael K. Georgieff,Gary M. Brittenham,Susan J. Fairweather-Tait,Richard F. Hurrell,Harry J. McArdle,Daniel J Raiten +7 more
TL;DR: A full appreciation of folate's history as a public health issue, its biology, and an overview of available biomarkers and their interpretation across a range of clinical and population-based uses are provided.
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Efficacy of deferoxamine in preventing complications of iron overload in patients with thalassemia major.
Gary M. Brittenham,Patricia Griffith,Arthur W. Nienhuis,Christine E. McLaren,Neal S. Young,Eben E. Tucker,Christopher J. Allen,David E. Farrell,John W. Harris +8 more
TL;DR: The early use of deferoxamine in an amount proportional to the transfusional iron load reduces the body iron burden and helps protect against diabetes mellitus, cardiac disease, and early death in patients with thalassemia major.
Journal ArticleDOI
Hepatic Iron Concentration and Total Body Iron Stores in Thalassemia Major
Emanuele Angelucci,Gary M. Brittenham,Christine E. McLaren,Marta Ripalti,Donatella Baronciani,Claudio Giardini,Maria Galimberti,Paola Polchi,Guido Lucarelli +8 more
TL;DR: The hepatic iron concentration is a reliable indicator of total body iron stores in patients with thalassemia major and in patientsWith transfusion-related iron overload, repeated determinations of the hepaticIron concentration can provide a quantitative means of measuring the long-term iron balance.
Journal ArticleDOI
Experimental liver cirrhosis induced by alcohol and iron.
Hidekazu Tsukamoto,Walter I. Horne,Seiichiro Kamimura,Onni Niemelä,Seppo Parkkila,Seppo Ylä-Herttuala,Gary M. Brittenham +6 more
TL;DR: Evidence is provided for a critical role of iron and iron-catalyzed oxidant stress in progression of alcoholic liver disease by intragastrically infused rats with or without ethanol to determine if alcoholic liver fibrogenesis is exacerbated by dietary iron supplementation.